{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:05:43Z","timestamp":1769828743537,"version":"3.49.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p> Chronic administration of anorexigenic substances to experimental animals by injections or continuous infusion typically produces either no effect or a transient reduction in food intake and body weight. Our aim here was to identify an intermittent dosing strategy for intraperitoneal infusion of peptide YY(3-36) [PYY(3-36)] that produces a sustained reduction in daily food intake and adiposity in diet-induced obese rats. Rats (665 \u00b1 10 g body wt, 166 \u00b1 7 g body fat) with intraperitoneal catheters tethered to infusion swivels had free access to a high-fat diet. Vehicle-treated rats ( n = 23) had relatively stable food intake, body weight, and adiposity during the 9-wk test period. None of 15 PYY(3-36) dosing regimens administered in succession to a second group of rats ( n = 22) produced a sustained 15\u201325% reduction in daily food intake for &gt;5 days, although body weight and adiposity were reduced across the 9-wk period by 12% (594 \u00b1 15 vs. 672 \u00b1 15 g) and 43% (96 \u00b1 7 vs. 169 \u00b1 9 g), respectively. The declining inhibitory effect of PYY(3-36) on daily food intake when the interinfusion interval was \u22653 h appeared to be due in part to an increase in food intake between infusions. The declining inhibitory effect of PYY(3-36) on daily food intake when the interinfusion interval was &lt; 3 h suggested possible receptor downregulation and tolerance to frequent PYY(3-36) administration; however, food intake significantly increased when PYY(3-36) treatments were discontinued for 1 day following apparent loss in treatment efficacies. Together, these results demonstrate the development of a potent homeostatic response to increase food intake when PYY(3-36) reduces food intake and energy reserves in diet-induced obese rats. <\/jats:p>","DOI":"10.1152\/ajpregu.00040.2008","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T21:35:26Z","timestamp":1213306526000},"page":"R449-R458","source":"Crossref","is-referenced-by-count":28,"title":["Effects of different intermittent peptide YY (3-36) dosing strategies on food intake, body weight, and adiposity in diet-induced obese rats"],"prefix":"10.1152","volume":"295","author":[{"given":"Roger D.","family":"Reidelberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvin C.","family":"Haver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanth K.","family":"Chelikani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Buescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.195"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2000.38"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1385\/MB:33:3:239"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/35007544"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00674.2005"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1138"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.08.001"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00386.2007"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00164.2007"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/302703a0"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30227"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.001"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01057-3"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2002.0231"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1301\/002966402760240372"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1054\/npep.1999.0050"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.3.G586"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1126\/science.306.5701.1453a"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.02.003"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00311.2007"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.08.054"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1988.254.1.R17"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00297.2007"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803284"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90534-0"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.06.011"},{"key":"R27","unstructured":"Persson P. 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