{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:43:53Z","timestamp":1791859433226,"version":"4.3.4"},"reference-count":39,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","doi-asserted-by":"publisher","award":["R01 NS091066"],"award-info":[{"award-number":["R01 NS091066"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["R01 DK 112198"],"award-info":[{"award-number":["R01 DK 112198"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["R01 HL133505"],"award-info":[{"award-number":["R01 HL133505"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:p> The sympathetic nerve activity (SNA) to brown adipose tissue (BAT) regulates BAT thermogenesis to defend body temperature in cold environments or to produce fever during immune responses. The vagus nerve contains afferents that inhibit the BAT SNA and BAT thermogenesis evoked by skin cooling. We sought to determine whether activation of transient receptor potential vanilloid 1 (TRPV1) channels in the nucleus tractus solitarius (NTS), which are prominently expressed in unmyelinated vagal afferents, would affect cold-evoked BAT thermogenesis, cardiovascular parameters, or their vagal afferent-evoked responses. In urethane-chloralose-anesthetized rats, during skin cooling, nanoinjection of the TRPV1-agonist resiniferatoxin in NTS decreased BAT SNA (from 695 \u00b1 195% of baseline during cooling to 103 \u00b1 8% of baseline after resiniferatoxin), BAT temperature (\u22120.8 \u00b1 0.1\u00b0C), expired CO<jats:sub>2<\/jats:sub> (\u22120.3 \u00b1 0.04%), mean arterial pressure (MAP; \u221220 \u00b1 5 mmHg), and heart rate (\u221244 \u00b1 11 beats\/min). Pretreatment of NTS with the TRPV1 antagonist capsazepine prevented these resiniferatoxin-mediated effects. Intravenous injection of the TRPV1 agonist dihydrocapsaicin also decreased all the measured variables (except MAP). Bilateral cervical or subdiaphragmatic vagotomy attenuated the decreases in BAT SNA and thermogenesis evoked by nanoinjection of resiniferatoxin in NTS but did not prevent the decreases in BAT SNA and BAT thermogenesis evoked by intravenous dihydrocapsaicin. We conclude that activation of TRPV1 channels in the NTS of vagus nerve intact rats inhibits BAT SNA and decreases BAT metabolism, blood pressure, and heart rate. In contrast, the inhibition of BAT thermogenesis following systemic administration of dihydrocapsaicin does not require vagal afferent activity, consistent with a nonvagal pathway through which systemic TRPV1 agonists can inhibit BAT thermogenesis. <\/jats:p>","DOI":"10.1152\/ajpregu.00049.2018","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T11:36:58Z","timestamp":1522237018000},"page":"R134-R143","source":"Crossref","is-referenced-by-count":34,"title":["Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate"],"prefix":"10.1152","volume":"315","author":[{"given":"Mazher","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Oregon Health &amp; Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-5695","authenticated-orcid":false,"given":"Christopher J.","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Oregon Health &amp; 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