{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:26:33Z","timestamp":1755033993150,"version":"3.35.0"},"reference-count":46,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>ROMK null mice with a high survival rate and varying severity of hydronephrosis provide a good model to study type II Bartter syndrome pathophysiology ( 26 ). During the development of such a colony, we found that more male than female null mice survived, 58.7% vs. 33.3%. To investigate the possible mechanism of this difference, we compared the survival rates, renal functions, degree of hydronephrosis, as well as PGE<jats:sub>2<\/jats:sub>and TXB<jats:sub>2<\/jats:sub>production between male and female ROMK wild-type and null mice. We observed that female ROMK Bartter's mice exhibited lower GFR (0.37 vs. 0.54 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 g BW<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05) and higher fractional Na<jats:sup>+<\/jats:sup>excretion (0.66% vs. 0.48%, P &lt; 0.05) than male Bartter's. No significant differences in acid-base parameters, urinary K<jats:sup>+<\/jats:sup>excretion, and plasma electrolyte concentrations were observed between sexes. In addition, we assessed the liquid retention rate in the kidney to evaluate the extent of hydronephrosis and observed that 67% of male and 90% of female ROMK null mice were hydronephrotic mice. Urinary PGE<jats:sub>2<\/jats:sub>excretion was higher in both sexes of ROMK null mice: 1.35 vs. 1.10 ng\/24 h in males and 2.90 vs. 0.87 ng\/24 h in females. TXB<jats:sub>2<\/jats:sub>excretion was higher in female mice in both wild-type and ROMK null mice. The increments of urinary PGE<jats:sub>2<\/jats:sub>and TXB<jats:sub>2<\/jats:sub>were significantly higher in female null mice than males, 233.33% vs. 22.74% of PGE<jats:sub>2<\/jats:sub>and 85.67% vs. 20.36% of TXB<jats:sub>2<\/jats:sub>. These data demonstrate a more severe Bartter phenotype in female ROMK null mice, and higher PGE<jats:sub>2<\/jats:sub>and TXB<jats:sub>2<\/jats:sub>production may be one of the mechanisms of this manifestation.<\/jats:p>","DOI":"10.1152\/ajpregu.00051.2007","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T00:55:08Z","timestamp":1214441708000},"page":"R997-R1004","source":"Crossref","is-referenced-by-count":18,"title":["Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher 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