{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:30:47Z","timestamp":1773279047817,"version":"3.50.1"},"reference-count":36,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"United States Department of Agriculture (USDA) National Institute on Aging","award":["2022-67013-36917"],"award-info":[{"award-number":["2022-67013-36917"]}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"crossref","award":["6054-41000-113-000D"],"award-info":[{"award-number":["6054-41000-113-000D"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006481","name":"Cotton Incorporated","doi-asserted-by":"publisher","award":["19-056"],"award-info":[{"award-number":["19-056"]}],"id":[{"id":"10.13039\/100006481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:p> A high-fat (HF) diet causes fatty liver, hyperlipidemia, and hypercholesterolemia, and cottonseed oil (CSO) has been shown to improve liver and plasma lipids in human and mouse models. The purpose of this study was to determine the effect of CSO vs. olive oil (OO)-enriched diets on lipid levels in a HF-diet model of fatty liver disease. We placed mice on a HF diet to induce obesity and fatty liver, after which mice were placed on CSO or OO diets, with chow and HF (5.1 kcal\/g) groups as control. When CSO- and OO-fed mice were given isocaloric diets with the HF group, there were no differences in body weight, plasma, or hepatic lipids. However, when the CSO and OO diets were reduced in calories (4.0 kcal\/g), CSO and OO groups reduced body weight. The CSO group had lower plasma total cholesterol (\u221256 \u00b1 6%, P &lt; 0.01), free cholesterol (\u221253 \u00b1 7%, P &lt; 0.01), triglycerides (\u221261 \u00b1 14%, P &lt; 0.01), and LDL (\u221242 \u00b1 16%, P = 0.01) vs. HF group whereas the OO diet lowered LDL (\u221218 \u00b1 12%, P = 0.05) vs. HF. Furthermore, the CSO diet decreased hepatic total cholesterol (\u221240 \u00b1 12%, P &lt; 0.01), free cholesterol (\u221223 \u00b1 11%, P = 0.04), and triglycerides (\u221247 \u00b1 12%, P = 0.02). There were no significant changes in lipogenesis and fatty acid oxidation among the groups. However, the CSO group increased lipid oxidative gene expression in liver and dihydrosterculic acid increased PPAR\u03b1 target genes with in vitro models. Taken together, consuming a reduced calorie diet enriched in CSO reduces liver and plasma lipid profiles in an obese model of fatty liver. <\/jats:p>","DOI":"10.1152\/ajpregu.00052.2022","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T13:44:50Z","timestamp":1670852690000},"page":"R171-R182","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["A cottonseed oil-enriched diet improves liver and plasma lipid levels in a male mouse model of fatty liver"],"prefix":"10.1152","volume":"324","author":[{"given":"Yura","family":"Son","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Shockey","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Southern Regional Research 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