{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T05:20:45Z","timestamp":1722835245671},"reference-count":37,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p> It was investigated whether skeletal muscle K<jats:sup>+<\/jats:sup> release is linked to the degree of anaerobic energy production. Six subjects performed an incremental bicycle exercise test in normoxic and hypoxic conditions prior to and after 2 and 8 wk of acclimatization to 4,100 m. The highest workload completed by all subjects in all trials was 260 W. With acute hypoxic exposure prior to acclimatization, venous plasma [K<jats:sup>+<\/jats:sup>] was lower ( P &lt; 0.05) in normoxia (4.9 \u00b1 0.1 mM) than hypoxia (5.2 \u00b1 0.2 mM) at 260 W, but similar at exhaustion, which occurred at 400 \u00b1 9 W and 307 \u00b1 7 W ( P &lt; 0.05), respectively. At the same absolute exercise intensity, leg net K<jats:sup>+<\/jats:sup> release was unaffected by hypoxic exposure independent of acclimatization. After 8 wk of acclimatization, no difference existed in venous plasma [K<jats:sup>+<\/jats:sup>] between the normoxic and hypoxic trial, either at submaximal intensities or at exhaustion (360 \u00b1 14 W vs. 313 \u00b1 8 W; P &lt; 0.05). At the same absolute exercise intensity, leg net K<jats:sup>+<\/jats:sup> release was less ( P &lt; 0.001) than prior to acclimatization and reached negative values in both hypoxic and normoxic conditions after acclimatization. Moreover, the reduction in plasma volume during exercise relative to rest was less ( P &lt; 0.01) in normoxic than hypoxic conditions, irrespective of the degree of acclimatization (at 260 W prior to acclimatization: \u22124.9 \u00b1 0.8% in normoxia and \u221210.0 \u00b1 0.4% in hypoxia). It is concluded that leg net K<jats:sup>+<\/jats:sup> release is unrelated to anaerobic energy production and that acclimatization reduces leg net K<jats:sup>+<\/jats:sup> release during exercise. <\/jats:p>","DOI":"10.1152\/ajpregu.00062.2010","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T03:07:55Z","timestamp":1271905675000},"page":"R306-R313","source":"Crossref","is-referenced-by-count":5,"title":["Human muscle net K<sup>+<\/sup> release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m"],"prefix":"10.1152","volume":"299","author":[{"given":"Nikolai B.","family":"Nordsborg","sequence":"first","affiliation":[{"name":"Department of Exercise and Sport Sciences, Faculty of Science, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A. L.","family":"Calbet","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen \u00d8, Denmark;"},{"name":"Department of Physical Education, University of Las Palmas de Gran Canaria, Palmas de Gran Canaria, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Sander","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen \u00d8, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"van Hall","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen \u00d8, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Copenhagen, Copenhagen, Denmark; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Saltin","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen \u00d8, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Lundby","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen \u00d8, Denmark;"},{"name":"Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015794"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021618"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000335"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011814"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.2.C598"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/343375a0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.49"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.2.634"},{"key":"B11","first-page":"176P","volume":"371","author":"Greig C","year":"1985","journal-title":"J Physiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1996.187000.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020179"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.165605"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110707"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s004210100517"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035899"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.2.R400"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.146035"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00725.2003"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2004.405.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.106765"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2002.01030.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376437"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2008.1009"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050658"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00029.2003"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.002"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1152\/ajplegacy.1959.197.6.1211","volume":"197","author":"Renkin EM","year":"1959","journal-title":"Am J Physiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00114.2004"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.4.1411"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3109\/00365517709098927"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.094615"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086801"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00963.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160846"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00943381"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00062.2010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:28:41Z","timestamp":1567960121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00062.2010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1152\/ajpregu.00062.2010"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00062.2010","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}