{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:00Z","timestamp":1785499800272,"version":"3.56.0"},"reference-count":74,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p> The sympathetic nervous system (SNS) is an important mediator of fetal adaptation to life-threatening in utero challenges, such as asphyxia. Although the SNS is active well before term, SNS responses mature significantly over the last third of gestation, and its functional contribution to adaptation to asphyxia over this critical period of life remains unclear. Therefore, we examined the hypotheses that increased renal sympathetic nerve activity (RSNA) is the primary mediator of decreased renal vascular conductance (RVC) during complete umbilical cord occlusion in preterm fetal sheep (101 \u00b1 1 days; term 147 days) and that near-term fetuses (119 \u00b1 0 days) would have a more rapid initial vasomotor response, with a greater increase in RSNA. Causality of the relationship of RSNA and RVC was investigated using surgical (preterm) and chemical (near-term) denervation. All fetal sheep showed a significant increase in RSNA with occlusion, which was more sustained but not significantly greater near-term. The initial fall in RVC was more rapid in near-term than preterm fetal sheep and preceded the large increase in RSNA. These data suggest that although RSNA can increase as early as 0.7 gestation, it is not the primary determinant of RVC. This finding was supported by denervation studies. Interestingly, chemical denervation in near-term fetal sheep was associated with an initial fall in blood pressure, suggesting that by 0.8 gestation sympathetic innervation of nonrenal vascular beds is critical to maintain arterial blood pressure during the rapid initial adaptation to asphyxia. <\/jats:p>","DOI":"10.1152\/ajpregu.00063.2012","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T04:26:21Z","timestamp":1336019181000},"page":"R30-R38","source":"Crossref","is-referenced-by-count":23,"title":["Renal sympathetic nerve activity during asphyxia in fetal sheep"],"prefix":"10.1152","volume":"303","author":[{"given":"Lindsea C.","family":"Booth","sequence":"first","affiliation":[{"name":"Department of Physiology, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Malpas","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of 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