{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:34:04Z","timestamp":1761561244639},"reference-count":52,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Enhancing perinatal nitric oxide (NO) availability persistently reduces blood pressure in spontaneously hypertensive rats. We hypothesize that this approach can be generalized to other models of genetic hypertension, for instance those associated with renal injury. Perinatal exposure to the NO donor molsidomine was studied in fawn-hooded hypertensive (FHH) rats, a model of mild hypertension, impaired preglomerular resistance, and progressive renal injury. Perinatal molsidomine increased urinary NO metabolite excretion at 8 wk of age, i.e., 4 wk after treatment was stopped ( P &lt; 0.05). Systolic blood pressure was persistently reduced after molsidomine (42-wk females: 118 \u00b1 3 vs. 141 \u00b1 5 and 36-wk males: 139 \u00b1 4 vs. 158 \u00b1 4 mmHg; both P &lt; 0.001). Perinatal treatment decreased glomerular filtration rate ( P &lt; 0.05) and renal blood flow ( P &lt; 0.01) and increased renal vascular resistance ( P &lt; 0.05), without affecting filtration fraction, suggesting persistently increased preglomerular resistance. At 4 wk of age natriuresis was transiently increased by molsidomine ( P &lt; 0.05). Molsidomine decreased glomerulosclerosis ( P &lt; 0.05). Renal blood flow correlated positively with glomerulosclerosis in control ( P &lt; 0.001) but not in perinatally treated FHH rats. NO dependency of renal vascular resistance was increased by perinatal molsidomine. Perinatal enhancement of NO availability can ameliorate development of hypertension and renal injury in FHH rats. Paradoxically, glomerular protection by perinatal exposure to the NO donor molsidomine may be due to persistently increased preglomerular resistance. The mechanisms by which increased perinatal NO availability can persistently reprogram kidney function and ameliorate hypertension deserve further study.<\/jats:p>","DOI":"10.1152\/ajpregu.00073.2008","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T01:38:15Z","timestamp":1208396295000},"page":"R1847-R1855","source":"Crossref","is-referenced-by-count":22,"title":["A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats"],"prefix":"10.1152","volume":"294","author":[{"given":"Maarten P.","family":"Koeners","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branko","family":"Braam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionne M.","family":"van der Giezen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel","family":"Goldschmeding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap A.","family":"Joles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000054212.23528.B2"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1979.236.3.F246"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00359.2002"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00313.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0344"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00101.2006"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00406.x"},{"key":"R8","unstructured":"Carmines PK, Perry MD, Hazelrig JB, Navar LG.Effects of preglomerular and postglomerular vascular resistance alterations on filtration fraction.Kidney Int Suppl20: S229\u2013S232, 1987."},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.2.F312"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198312000-00005"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.3.F365"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005231"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1977.120"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00526.2004"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701098"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1990.tb01871.x"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06751"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20590"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018020-00001"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00019.2002"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1761.2007.01702.x"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095794"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Kristek F, Faberova V, Varga I.Long-term effect of molsidomine and pentaerythrityl tetranitrate on cardiovascular system of spontaneously hypertensive rats.Physiol Res52: 709\u2013717, 2003.","DOI":"10.33549\/physiolres.930365"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00402.2005"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00347.2006"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00012.2007"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00053.2003"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000188702.96256.46"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1159\/000180762"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3282f34b02"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00314.2004"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000133251.40322.20"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00348.2002"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4184(19995)332:5<182::AID-ARDP182>3.0.CO;2-Z"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.3109\/10641968009037132"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000052833.20759.64"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04643.x"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04544.x"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90119-1"},{"key":"R40","unstructured":"Simons JL, Provoost AP, Anderson S, Troy JL, Rennke HG, Sandstrom DJ, Brenner BM.Pathogenesis of glomerular injury in the fawn-hooded rat: early glomerular capillary hypertension predicts glomerular sclerosis.J Am Soc Nephrol3: 1775\u20131782, 1993."},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.1007"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Turkstra E, Braam B, Koomans HA.Impaired renal blood flow autoregulation in two-kidney, one-clip hypertensive rats is caused by enhanced activity of nitric oxide.J Am Soc Nephrol11: 847\u2013855, 2000.","DOI":"10.1681\/ASN.V115847"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000301"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00722.x"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00163-5"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Van Dokkum RP, Jacob HJ, Provoost AP.Genetic differences define severity of renal damage afterl-NAME-induced hypertension in rats.J Am Soc Nephrol9: 363\u2013371, 1998.","DOI":"10.1681\/ASN.V93363"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.3.R855"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.4.F664"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.4.893"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1159\/000190299"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.5212"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00250.2005"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00073.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T05:25:57Z","timestamp":1708838757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00073.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1152\/ajpregu.00073.2008"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00073.2008","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}