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After the baseline brachial blood flow and vascular conductance decreased and became stable in progress of postoperative recovery, the static exercise experiments were started. Brachial blood flow and vascular conductance began to increase simultaneously with the onset of exercise. Their initial increases reached 52 \u00b1 8% and 40 \u00b1 6% at 3 s from the exercise onset, respectively. Both a sympathetic ganglionic blocker (hexamethonium bromide) and atropine sulfate or methyl nitrate blunted the increase in brachial vascular conductance at the onset of static exercise, whereas an inhibitor of nitric oxide synthesis ( N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine methyl ester) did not alter the increase in brachial vascular resistance. Brachial blood flow and vascular conductance increased during natural grooming behavior with the forelimb in which the flow probe was implanted, whereas they decreased during grooming with the opposite forelimb and during eating behavior. Thus it is likely that the sympathetic cholinergic mechanism is capable of evoking muscle vasodilatation at the onset of voluntary static exercise in conscious cats.<\/jats:p>","DOI":"10.1152\/ajpregu.00076.2008","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T01:58:52Z","timestamp":1218679132000},"page":"R1251-R1262","source":"Crossref","is-referenced-by-count":16,"title":["Sympathetic cholinergic nerve contributes to increased muscle blood flow at the onset of voluntary static exercise in conscious cats"],"prefix":"10.1152","volume":"295","author":[{"given":"Hidehiko","family":"Komine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Tsuchimochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006593"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007371"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Adams DB, Baccelli G, Mancia G, Zanchetti A.Cardiovascular changes during naturally elicited fighting behavior in the cat.Am J Physiol216: 1226\u20131235, 1969.","DOI":"10.1152\/ajplegacy.1969.216.5.1226"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009327"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200208000-00009"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb01525.x"},{"key":"R7","unstructured":"Barcroft H, Brod J, Hejl Z, Hirsjarvi EA, Kitchin AH.The mechanism of the vasodilatation in the forearm muscle during stress (mental arithmetic).Clin Sci19: 577\u2013586, 1960."},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006312"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1970.tb04638.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2249"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.5.H1872"},{"key":"R12","unstructured":"Burnstock G.Cholinergic and purinergic regulation of blood vessels. 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