{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:04:17Z","timestamp":1782345857679,"version":"3.54.5"},"reference-count":51,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL51971"],"award-info":[{"award-number":["P01 HL51971"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM104357"],"award-info":[{"award-number":["P20 GM104357"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115428"],"award-info":[{"award-number":["U54GM115428"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p> The main goal of this study was to compare the impact of total body leptin deficiency with neuronal-specific leptin receptor (LR) deletion on metabolic and cardiovascular regulation. Liver fat, diacylglycerol acyltransferase-2 (DGTA2), and CD36 protein content were measured in wild-type (WT), nervous system LR-deficient (LR\/Nestin-Cre), and leptin deficient ( ob\/ob) mice. Blood pressure (BP) and heart rate (HR) were recorded by telemetry, and motor activity (MA) and oxygen consumption (V\u0307o<jats:sub>2<\/jats:sub>) were monitored at 24 wk of age. Female and male LR\/Nestin-Cre and ob\/ob mice were heavier than WT mice (62\u2009\u00b1\u20095 and 61\u2009\u00b1\u20093 vs. 31\u2009\u00b1\u20091 g) and hyperphagic (6.2\u2009\u00b1\u20090.5 and 6.1\u2009\u00b1\u20090.7 vs. 3.5\u2009\u00b1\u20091.0 g\/day), with reduced V\u0307o<jats:sub>2<\/jats:sub> (27\u2009\u00b1\u20091 and 33\u2009\u00b1\u20091 vs 49\u2009\u00b1\u20093 ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) and decreased MA (3\u2009\u00b1\u20091 and 7\u2009\u00b1\u20092 vs 676\u2009\u00b1\u2009105 cm\/h). They were also hyperinsulinemic and hyperglycemic compared with WT mice. LR\/Nestin-Cre mice had high levels of plasma leptin, while ob\/ob mice had undetectable leptin levels. Despite comparable obesity, LR\/Nestin-Cre mice had lower liver fat content, DGTA2, and CD36 protein levels than ob\/ob mice. Male WT, LR\/Nestin-Cre, and ob\/ob mice exhibited similar BP (111\u2009\u00b1\u20093, 110\u2009\u00b1\u20091 and 109\u2009\u00b1\u20092 mmHg). Female LR\/Nestin-Cre and ob\/ob mice, however, had higher BP than WT females despite similar metabolic phenotypes compared with male LR\/Nestin-Cre and ob\/ob mice. These results indicate that although nervous system LRs play a crucial role in regulating body weight and glucose homeostasis, peripheral LRs regulate liver fat deposition. In addition, our results suggest potential sex differences in the impact of obesity on BP regulation. <\/jats:p>","DOI":"10.1152\/ajpregu.00077.2019","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T14:25:47Z","timestamp":1565792747000},"page":"R552-R562","source":"Crossref","is-referenced-by-count":19,"title":["Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation"],"prefix":"10.1152","volume":"317","author":[{"given":"Jussara M.","family":"do Carmo","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Mississippi Center for Obesity 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