{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:52:25Z","timestamp":1780645945812,"version":"3.54.1"},"reference-count":188,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135158"],"award-info":[{"award-number":["HL135158"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135158S1"],"award-info":[{"award-number":["HL135158S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:p>Blood pressure regulation in health and disease involves a balance between afferent and efferent signals from multiple organs and tissues. Although there are numerous reviews focused on the role of sympathetic nerves in different models of hypertension, few have revised the contribution of afferent nerves innervating adipose tissue and their role in the development of obesity-induced hypertension. Both clinical and basic research support the beneficial effects of bilateral renal denervation in lowering blood pressure. However, recent studies revealed that afferent signals from adipose tissue, in an adipose-brain-peripheral pathway, could contribute to the increased sympathetic activation and blood pressure during obesity. This review focuses on the role of adipose tissue afferent reflexes and briefly describes a number of other afferent reflexes modulating blood pressure. A comprehensive understanding of how multiple afferent reflexes contribute to the pathophysiology of essential and\/or obesity-induced hypertension may provide significant insights into improving antihypertensive therapeutic approaches.<\/jats:p>","DOI":"10.1152\/ajpregu.00079.2019","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T15:39:58Z","timestamp":1577115598000},"page":"R379-R389","source":"Crossref","is-referenced-by-count":20,"title":["Sensory signals mediating high blood pressure via sympathetic activation: role of adipose afferent reflex"],"prefix":"10.1152","volume":"318","author":[{"given":"Carolina","family":"Dalmasso","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline R.","family":"Leachman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-2146","authenticated-orcid":false,"given":"Analia S.","family":"Loria","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312156"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041244.79165.25"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9054-9_3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07850"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00416.2017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07850"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.5.R1399"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2004409"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.031"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.04.002"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.182"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.264.5.H1674"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00558.2003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy156"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.878"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90456-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.32"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2003"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190412"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003736"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/513214"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.054353"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12447"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00826.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1997.273.5.F712"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.42.030180.002213"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.029041"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3565.387"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000189183.50301.5c"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12125"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003751"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03640.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00461"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2017.10.005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2019.02.001"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.02.002"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2008.0274"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000113047.47711.fa"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.5.R1517"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.1.75"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136983"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2006-0"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12502"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/srep34374"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083771"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0658-1"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.5.676"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.145"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.04.014"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.6.717"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.253.6.R942"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1113\/EP087700"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3053-9.50009-3"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121258"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00681.2006"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000168056.66981.c2"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01097.2003"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.06.013"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.54.4.378"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382756"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11038"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.02.015"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1902"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10921"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.113175"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305697"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0145-4"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386525-0.00004-4"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.5.H1466"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199512020-00002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/advances.1999.277.6.S234"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-5223-1"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.140665"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08293"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.06.016"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00644.2016"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-016-0073-8"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00206.2005"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198906000-00003"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100043"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92946-0_8"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.3.807"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01083.x"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-39632-5.00019-0"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.50.1.133"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081682"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17741-1"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01249"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1113\/JP274537"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08372"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.2217\/fca.16.5"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00351.2014"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00493.2003"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00336.2002"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00830.2007"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.6.R1780"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.9"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.208"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.094649"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.163"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080295"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00625.2005"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3109\/08037059209065120"},{"key":"B105","volume-title":"Molecular Cell Biology","author":"Lodish H","year":"2000","edition":"4"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00035.2014"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386525-0.00038-X"},{"key":"B108","first-page":"125","volume":"18","author":"Longhurst JC","year":"1979","journal-title":"Int Rev Physiol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03676.x"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X1997000400015"},{"key":"B111","first-page":"161","volume-title":"Capsaicin in the Study of Pain","author":"Maggi CA","year":"1993"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.099200"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040068"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011626"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90082-6"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.3.1265"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1152\/nips.01470.2003"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.cp020317"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181942f3c"},{"key":"B120","first-page":"59","volume":"15","author":"Moss NG","year":"1989","journal-title":"Miner Electrolyte Metab"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3109\/10641968709160160"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1982.243.5.F425"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.05.021"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00599.2012"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00021.2013"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1201534"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.11.006"},{"key":"B129","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/cphy.c100083","volume":"2","author":"Nattie E","year":"2012","journal-title":"Compr Physiol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.02.019"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00109-X"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00054-3"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303603"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1139\/y87-244"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.08928"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.50.1.125"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.2.175"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.6.R1781"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4173"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.03.005"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.072678"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00283-9"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.00920"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(81)90066-7"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1966.tb03320.x"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00060.2014"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00456.2015"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0625-x"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1998)11:1<29:AID-CA4>3.0.CO;2-N"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00082"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1973.53.4.916"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03665.x"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00235-X"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03673.x"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-016-0137-4"},{"key":"B157","first-page":"17","volume":"10","author":"Sheng Y","year":"2018","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00036.2005"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00648.2004"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01164.2011"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0097"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.18.5_Suppl.III31"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.01.87"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90786.2008"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.3.659"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.08936"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00234-8"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03681.x"},{"key":"B169","first-page":"923","volume":"255","author":"Szolcsanyi J","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.6.H2843"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3109\/07435809809032687"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.2174\/1568016033477540"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.10.027"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00057.x"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1113\/JP273764"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03699"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9676-y"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009898107964"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.09.032"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198710000-00009"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.198002"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12182"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.154630"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-019-00417-1"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.08.008"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-018-0316-5"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01245.2003"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.046565"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-002-0353-z"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00079.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T07:29:26Z","timestamp":1665300566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00079.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":188,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,1]]}},"alternative-id":["10.1152\/ajpregu.00079.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00079.2019","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,1]]}}}