{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:35:58Z","timestamp":1776710158103,"version":"3.51.2"},"reference-count":46,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022ZW3M8H"],"award-info":[{"award-number":["2022ZW3M8H"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC_2023"],"award-info":[{"award-number":["RC_2023"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","award":["Vera Srebot"],"award-info":[{"award-number":["Vera Srebot"]}],"id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>The results underscore a multifaceted interaction among cardiopulmonary hemodynamics, right heart pressures, ventilatory response, and autonomic regulation. In particular, altered RV-PA coupling correlated with heightened sympathetic drive, indicating that cardiopulmonary efficiency and hemodynamics may influence central autonomic outputs. This suggests that mechanical stress or overload in the right heart could modulate sympathovagal balance, thereby contributing to altered autonomic responses during exercise in patients with cardiopulmonary disorders.<\/jats:p>","DOI":"10.1152\/ajpregu.00094.2025","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:10:24Z","timestamp":1774278624000},"page":"R480-R488","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interplay of pulmonary circulation, cardiac filling pressures, and sympathovagal balance in exercise-induced hyperventilation among cardiopulmonary disorders"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-4555","authenticated-orcid":false,"given":"Marco","family":"Vicenzi","sequence":"first","affiliation":[{"name":"ASST Rhodense, Garbagnate Milanese Hospital","place":["Italy"]},{"name":"University of Milan","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-2954","authenticated-orcid":false,"given":"Gabriel","family":"Dias Rodrigues","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]},{"name":"Fluminense Federal University (UFF)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-6499","authenticated-orcid":false,"given":"Sergio","family":"Caravita","sequence":"additional","affiliation":[{"name":"University of Bergamo","place":["Italy"]},{"name":"ASST Papa Giovanni XXIII","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-7815","authenticated-orcid":false,"given":"Gael","family":"Deboeck","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella","family":"Colombo","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Rota","sequence":"additional","affiliation":[{"name":"ASST Ovest Milanese","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mozzo","sequence":"additional","affiliation":[{"name":"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-1777","authenticated-orcid":false,"given":"Gregorio","family":"Tersalvi","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-8293","authenticated-orcid":false,"given":"Eleonora","family":"Tobaldini","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]},{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Carugo","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]},{"name":"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-0075","authenticated-orcid":false,"given":"Nicola","family":"Montano","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Italy"]},{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6358-7852","authenticated-orcid":false,"given":"Jean-Luc","family":"Vachiery","sequence":"additional","affiliation":[{"name":"H\u00f4pital Acad\u00e9mique Erasme","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-1045","authenticated-orcid":false,"given":"Philippe","family":"van de Borne","sequence":"additional","affiliation":[{"name":"H\u00f4pital Acad\u00e9mique Erasme","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00111904"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.686576"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.1.39"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2013.05.005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00523-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.1.218"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.940"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0318"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00342-2019"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.785501"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265059"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.12.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.967"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093699"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.04.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.824"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2221"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.01080732"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00145708"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00091609"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.5.913"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2903"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.7.1762"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.09.007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140724.90898.D3"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.157115"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027451"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01897-2018"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1016"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey042"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15097"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165382"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.518449"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2065"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.053"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120772"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00217911"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070292"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000204"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-020-09774-z"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.09.087"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.061"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.899290"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00094.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:36:02Z","timestamp":1776706562000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00094.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpregu.00094.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00094.2025","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}