{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:29:36Z","timestamp":1776205776554,"version":"3.50.1"},"reference-count":66,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100009238","name":"Swedish Armed Forces","doi-asserted-by":"crossref","award":["9220907"],"award-info":[{"award-number":["9220907"]}],"id":[{"id":"10.13039\/501100009238","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p> We examined the interactive effects of mild hypothermia and hypoxia on finger vasoreactivity to local cold stress. Eight male lowlanders performed, in a counterbalanced order, a normoxic and a hypoxic (partial pressure of oxygen: ~12 kPa) hand cold provocation (consisting of a 30-min immersion in 8\u00b0C water), while immersed to the chest either in 21\u00b0C [cold trials; 0.5\u00b0C fall in rectal temperature (T<jats:sub>rec<\/jats:sub>) from individual preimmersion values], or in 35.5\u00b0C water, or while exposed to 27\u00b0C air. The duration of the trials was kept constant in each breathing condition. Physiological (T<jats:sub>rec<\/jats:sub>, skin temperature, cutaneous vascular conductance, oxygen uptake) and perceptual (thermal sensation and comfort, local pain, affective valence) reactions were monitored continually. Hypoxia accelerated the drop in T<jats:sub>rec<\/jats:sub> by ~14 min ( P = 0.06, d\u2009=\u20090.67). In the air-exposure trials, hypoxia did not alter finger perfusion during the local cooling, whereas it impaired the finger rewarming response following the cooling ( P &lt; 0.01). During the 35.5\u00b0C immersion, the finger vasomotor tone was enhanced, especially in hypoxia ( P = 0.01). Mild hypothermia aggravated finger vasoconstriction instigated by local cooling ( P &lt; 0.01), but the response did not differ between the two breathing conditions ( P &gt; 0.05). Hypoxia tended to attenuate the sensation of coldness ( P = 0.10, r\u2009=\u20090.40) and thermal discomfort ( P = 0.09, r\u2009=\u20090.46) in the immersed hand. Both in normoxia and hypoxia, the whole body thermal state dictates the cutaneous vasomotor reactivity to localized cold stimulus. <\/jats:p>","DOI":"10.1152\/ajpregu.00103.2019","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T12:58:10Z","timestamp":1561553890000},"page":"R418-R431","source":"Crossref","is-referenced-by-count":20,"title":["Interactions of mild hypothermia and hypoxia on finger vasoreactivity to local cold stress"],"prefix":"10.1152","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7440-2171","authenticated-orcid":false,"given":"Michail E.","family":"Keramidas","sequence":"first","affiliation":[{"name":"Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"K\u00f6leg\u00e5rd","sequence":"additional","affiliation":[{"name":"Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor B.","family":"Mekjavic","sequence":"additional","affiliation":[{"name":"Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia"},{"name":"Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Eiken","sequence":"additional","affiliation":[{"name":"Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1943.00210050003001"},{"key":"B2","first-page":"592","volume":"43","author":"Arborelius M","year":"1972","journal-title":"Aerosp Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.3.R731"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.6.848"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2054"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2445"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/9.3.261"},{"key":"B8","volume-title":"Man in a Cold Environment. 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