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In response to food restriction, plasma leptin concentrations, core body temperature, and energy expenditure of the spiny mouse decrease significantly after 24 h, and most spiny mice are able to maintain their body mass to \u223c85% of ad libitum for a prolonged period of time. Both 1-day food deprivation and long-term food restriction had a significant effect on body mass and plasma leptin concentrations, which decreased significantly with a high correlation, as well as on the orexigenic agouti-related protein, which increased significantly as a result of the 24-h food deprivation; and on neuropeptide Y (NPY), in which the increase was more pronounced under long-term food restriction. Food restriction and food deprivation had no effect, however, on the anorexigenic pro-opiomelanocortin and cocaine and amphetamine-related transcript. Leptin administration to food-restricted spiny mice did not affect food intake or the rate of decrease in body mass, indicating that it cannot overcome the drive to eat when food is scarce. However, it did result in a significant decrease in NPY levels, and the spiny mice spent less time at low body temperatures compared with PBS-treated golden spiny mice. These results show that in food-restricted golden spiny mice, leptin affects thermogenesis, but not food consumption, and suggest that the thermoregulatory effects of leptin are mediated by NPY. <\/jats:p>","DOI":"10.1152\/ajpregu.00105.2008","type":"journal-article","created":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T01:09:46Z","timestamp":1223514586000},"page":"R2015-R2023","source":"Crossref","is-referenced-by-count":11,"title":["Effect of food availability and leptin on the physiology and hypothalamic gene expression of the golden spiny mouse: a desert rodent that does not hoard food"],"prefix":"10.1152","volume":"295","author":[{"given":"Roee","family":"Gutman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Hacmon-Keren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Choshniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noga","family":"Kronfeld-Schor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7105"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/382250a0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00481-9"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00734.2002"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0621"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/380677a0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(84)80039-0"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092514"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00587.2007"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800547"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.2.R328"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-005-0475-3"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00825.2007"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000771"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118206"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00716.2003"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00434.2002"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14623"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.5.R1627"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00068.2006"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00156.2005"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.033"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8878"},{"key":"R23A","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301619"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.027"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.11.004"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11852"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00495.2001"},{"key":"R29","unstructured":"Jaffe S. 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