{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:47:08Z","timestamp":1782402428862,"version":"3.54.5"},"reference-count":38,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-03891"],"award-info":[{"award-number":["RGPIN-2020-03891"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>We show that age-related impairments in exercise-induced autophagic regulation are more pronounced in older adults with hypertension and type 2 diabetes. Performing the same high-intensity exercise in the heat led to additional reductions in autophagic regulation in these individuals. Taken together, our findings provide new insights into cellular mechanisms that may underlie increased vulnerability to exertional heat stress in older adults, both with and without common chronic diseases.<\/jats:p>","DOI":"10.1152\/ajpregu.00115.2026","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:11:33Z","timestamp":1781100693000},"page":"R75-R85","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impacts of common chronic disease on autophagy and cellular stress during exertional heat stress in peripheral blood mononuclear cells of older males"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-2077","authenticated-orcid":false,"given":"James J.","family":"McCormick","sequence":"first","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli E.","family":"McCormick","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-3174","authenticated-orcid":false,"given":"Nicholas","family":"Goulet","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate P.","family":"Hutchins","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-6973","authenticated-orcid":false,"given":"Glen P.","family":"Kenny","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]},{"name":"Ottawa Hospital Research Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12876"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00790"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.05.007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.05.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/972807"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0653-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03599-7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00232.2024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s1534-5807(04)00099-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.018"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.462408"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1009776"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00261.2018"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01383-13"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.78"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00110.2022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00163.2023"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/EP092567"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1752511"},{"key":"B20","volume-title":"CSEP-PATH","author":"Canadian Society for Exercise Physiology","year":"2013"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29490"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00523.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.3.531"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200612000-00011"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1797280"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90541-3"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/361590"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13651"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01116.2014"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-267187"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00178.2024"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44535-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.08.004"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2337\/dbi20-0014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23923-1"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/life11090903"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204815"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00115.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:03:11Z","timestamp":1782399791000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00115.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/ajpregu.00115.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00115.2026","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}