{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:19:32Z","timestamp":1754486372696,"version":"3.37.3"},"reference-count":27,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["PULM-024-17S"],"award-info":[{"award-number":["PULM-024-17S"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:p> Typically, unit discharge of slowly adapting receptors (SARs) declines slowly when lung inflation pressure is constant, although in some units it increases instead\u2014a phenomenon hereinafter referred to as creeping. These studies characterize creeping behavior observed in 62 of 137 SAR units examined in anesthetized, open-chest, and mechanically ventilated rabbits. SAR units recorded from the cervical vagus nerve were studied during 4\u2009s of constant lung inflation at 10, 20, and 30 cmH<jats:sub>2<\/jats:sub>O. Affected SAR units creep more quickly as inflation pressure increases. SAR units also often deactivate after creeping, i.e., their activity decreases or stops completely. Creeping likely results from encoder switching from a low discharge to a high discharge SAR, because it disappears in SAR units with multiple receptive fields after blocking a high discharge encoder in one field leaves low discharge encoders intact. The results support that encoder switching is a common mechanism operating in lung mechanosensory units. <\/jats:p>","DOI":"10.1152\/ajpregu.00116.2021","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T12:44:48Z","timestamp":1625057088000},"page":"R220-R227","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Paradoxical response of pulmonary slowly adapting units during constant pressure lung inflation"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2336","authenticated-orcid":true,"given":"Jerry","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medicine University of Louisville, Louisville, Kentucky and Robley Rex VA Medical Center, Louisville, Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"395","volume-title":"Handbook of Physiology","author":"Coleridge HM","year":"1986"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00203-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00155.2006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00136.2020"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130020"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01286.2006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1983.245.2.R209"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90019-s"},{"key":"B9","first-page":"182","volume-title":"Airway Smooth Muscle: Modulation of Receptors and Response","author":"Bergren DR","year":"1990"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90088-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90039-X"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0713-0_1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.047"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2142"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(81)90028-1"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(88)90027-8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.6.1842"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1159\/000364947"},{"key":"B19","first-page":"689","volume":"57","author":"Winner E","year":"2005","journal-title":"Sheng Li Xue Bao"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(98)00410-x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00903.2015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00125.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00064.2019"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.6.2305"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.49.030187.003143"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00588"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103595"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00116.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T14:18:48Z","timestamp":1627913928000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00116.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["10.1152\/ajpregu.00116.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00116.2021","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"type":"print","value":"0363-6119"},{"type":"electronic","value":"1522-1490"}],"subject":[],"published":{"date-parts":[[2021,8,1]]},"assertion":[{"value":"2021-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}