{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:21:57Z","timestamp":1783570917299,"version":"3.55.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:p> A regulatory effect of arginine vasopressin (AVP) on sweat water conservation has been hypothesized but not definitively evaluated. AVP-mediated insertion of sweat and salivary gland aquaporin-5 (AQP5) water channels through activation of the vasopressin type 2 receptor (V2R) remains an attractive, yet unexplored, mechanism that could result in a more concentrated sweat with resultant decreased water loss. Ten runners participated in a double-blind randomized control treadmill trial under three separate pharmacological conditions: a placebo, V2R agonist (0.2 mg desmopressin), or V2R antagonist (30 mg tolvaptan). After a familiarization trial, runners ran for 60 min at 60% of peak speed followed by a performance trial to volitional exhaustion. Outcome variables were collected at three exercise time points: baseline, after the steady-state run, and after the performance run. Body weight losses were &lt;2% across all three trials. Significant pharmacological condition effects were noted for urine osmolality [ F = 84.98; P &lt; 0.0001] and urine sodium concentration ([Na<jats:sup>+<\/jats:sup>]) [ F = 38.9; P &lt; 0.0001], which verified both pharmacological activation and inhibition of the V2R at the kidney collecting duct. Plasma osmolality and [Na<jats:sup>+<\/jats:sup>] demonstrated significant exercise ( F = 26.0 and F = 11.1; P &lt; 0.0001) and condition ( F = 5.1 and F = 3.8; P &lt; 0.05) effects (osmolality and [Na<jats:sup>+<\/jats:sup>], respectively). No significant exercise or condition effects were noted for either sweat or salivary [Na<jats:sup>+<\/jats:sup>]. Significant exercise effects were noted for plasma [AVP] ( F = 22.3; P &lt; 0.0001), peak core temperature ( F = 103.3; P &lt; 0.0001), percent body weight change ( F = 6.3; P = 0.02), plasma volume change ( F = 21.8; P &lt; 0.0001), and thirst rating ( F = 78.2; P &lt; 0.0001). Performance time was not altered between conditions ( P = 0.80). In summary, AVP acting at V2R does not appear to regulate water losses from body fluids other than renal excretion during exercise. <\/jats:p>","DOI":"10.1152\/ajpregu.00120.2014","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T05:59:38Z","timestamp":1403157578000},"page":"R366-R375","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of the effects of the vasopressin V2 receptor on sweating, fluid balance, and performance during exercise"],"prefix":"10.1152","volume":"307","author":[{"given":"Tamara","family":"Hew-Butler","sequence":"first","affiliation":[{"name":"Exercise Science Program, Oakland University, Rochester, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Hummel","sequence":"additional","affiliation":[{"name":"Exercise Science Program, Oakland University, Rochester, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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