{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:42:39Z","timestamp":1794109359379,"version":"4.8.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"2","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.13"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03317"],"award-info":[{"award-number":["21H03317"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02828"],"award-info":[{"award-number":["24K02828"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>Pharmacological stimulation of \u03b1- and \u03b2-adrenergic receptors produces sweating in vivo. Still, the separate and interactive roles of these adrenergic receptors during exercise and pharmacological adrenergic stimulation in the heat remain unknown. We showed that \u03b2-adrenergic receptors may interact with \u03b1-adrenergic receptors pharmacologically, but it does not modulate exercise-induced sweating. The \u03b1-adrenergic receptors independently modulate sweating during exercise in the heat. We provide important new insights into our understanding of the mechanisms regulating human sweating.<\/jats:p>","DOI":"10.1152\/ajpregu.00120.2024","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T15:20:48Z","timestamp":1734708048000},"page":"R181-R194","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Separate and combined blockades of \u03b1- and \u03b2-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-6937","authenticated-orcid":false,"given":"Tatsuro","family":"Amano","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ww21r56","id-type":"ROR","asserted-by":"publisher"}],"name":"Niigata University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-8291","authenticated-orcid":false,"given":"Naoto","family":"Fujii","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-6973","authenticated-orcid":false,"given":"Glen P.","family":"Kenny","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-8543","authenticated-orcid":false,"given":"Toby","family":"M\u00fcndel","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Osaka International University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Yokoyama","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ww21r56","id-type":"ROR","asserted-by":"publisher"}],"name":"Niigata University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-408X","authenticated-orcid":false,"given":"Narihiko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Kobe University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(89)70081-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2741\/s94"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12497915"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20745"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20769"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14208"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-71-17287"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1981.240.1.R44"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.5.1701"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.3.930"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.3.899"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02342.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1973.tb08180.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.3.H855"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00228.2010"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.5.H1599"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199804000-00004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00242.2009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00370.2018"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04351-3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00220.2017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.12.006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1966.tb01851.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011584"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.4.1448"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1983.245.3.C189"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2183\/pjab1945.38.227"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4565(84)90051-2"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/EP088797"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/2515245920951503"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00523.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00456.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042283"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12523.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/JP271990"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13024"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.05.001"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00215-6"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267818"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00242.2022"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.3.531"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1519\/15184.1"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.26.517"},{"key":"B45","author":"Hedayati A","year":"2015","journal-title":"Social Pharmacy J"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2012.687449"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-021536-5.50013-7"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08740.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00252.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00261.2015"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/JP270147"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/BF01821532"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.94.117"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67505-8_2"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0922OC"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018862510646"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00120.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:58:43Z","timestamp":1744880323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00120.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"alternative-id":["10.1152\/ajpregu.00120.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00120.2024","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}