{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:09:44Z","timestamp":1780373384151,"version":"3.54.1"},"reference-count":28,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en G\u00e9nie du Canada)","doi-asserted-by":"publisher","award":["RGPIN 06637"],"award-info":[{"award-number":["RGPIN 06637"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"crossref","award":["WCHRIIG RES0018745"],"award-info":[{"award-number":["WCHRIIG RES0018745"]}],"id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"crossref","award":["WCHRI-GAP RES0028401"],"award-info":[{"award-number":["WCHRI-GAP RES0028401"]}],"id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000190","name":"University of Alberta (U of A)","doi-asserted-by":"publisher","award":["UOFAB-BF-VPA RES0028400"],"award-info":[{"award-number":["UOFAB-BF-VPA RES0028400"]}],"id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p> In pathological populations, elevated sympathetic activity is associated with increased activity of individual sympathetic neurons. We used custom action potential detection software to analyze multiunit sympathetic activity in 18 normotensive pregnant women (third trimester; 33\u2009\u00b1\u20095 wk) and 19 nonpregnant women at rest and a subset (10 and 13, respectively) during a cold pressor challenge. Although the number of action potentials per burst and number of active amplitude-based \u201cclusters\u201d were not different between groups, the total number of sympathetic action potentials per minute was higher in pregnant women at rest. Individual clusters were active predominately once per burst, suggesting they represent single neurons. Action potentials occurred in closer succession in normotensive pregnant (interspike interval 36 \u00b1 10 ms) versus nonpregnant women (50 \u00b1 27 ms; P &lt; 0.001) at rest. Pregnant women had a lower total peripheral resistance (11.7 \u00b1 3.0 mmHg\u00b7l<jats:sup>\u22121\u00b7<\/jats:sup>min) than nonpregnant women (15.1 \u00b1 2.7 mmHg\u00b7l<jats:sup>\u22121\u00b7<\/jats:sup>min; P &lt; 0.001), indicating a blunted neurovascular transduction. The cold pressor reduced the number of action potentials per burst in both groups due to shortening of the R-R interval in conjunction with increased burst frequency; total neural firing per minute was unchanged. Thus elevated sympathetic activity during normotensive pregnancy is specific to increased incidence of multiunit bursts. This is likely due to decreased central gating of burst output as opposed to generalized increases in central drive. These data also reinforce the concept that pregnancy appears to be the only healthy state of chronic sympathetic hyperactivity of which we are aware. <\/jats:p>","DOI":"10.1152\/ajpregu.00121.2016","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T13:35:23Z","timestamp":1508333723000},"page":"R153-R160","source":"Crossref","is-referenced-by-count":18,"title":["Activity of muscle sympathetic neurons during normotensive pregnancy"],"prefix":"10.1152","volume":"314","author":[{"given":"Sydney M. L.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Program for Pregnancy &amp; Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte W.","family":"Usselman","sequence":"additional","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Program for Pregnancy &amp; Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Martinek","sequence":"additional","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Stickland","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine &amp; Dentistry,\u00a0 University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen G.","family":"Julian","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Denver School of Medicine, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Chari","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine &amp; Dentistry, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rshmi","family":"Khurana","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Department of Medicine, University of Colorado Denver School of Medicine, Denver, Colorado"},{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine &amp; Dentistry, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra T.","family":"Davidge","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine &amp; Dentistry, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margie H.","family":"Davenport","sequence":"additional","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Program for Pregnancy &amp; Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada"},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig D.","family":"Steinback","sequence":"additional","affiliation":[{"name":"Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Program for Pregnancy &amp; Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada"},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.185348"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.4.844"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05158.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00899.2001"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1139\/h99-010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098253"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)03256-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816050-00009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.228262"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.238998"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.094649"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00153"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2003.002637"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.293aa.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020482"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00323.2012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1997.tb02693.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1985.tb07592.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.282277"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1109\/ICASSP.2010.5495604"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.08.035"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/66.3.605"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.195941"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267819"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00041-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00131.2015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05964"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00121.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T04:14:54Z","timestamp":1569384894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00121.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,1]]}},"alternative-id":["10.1152\/ajpregu.00121.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00121.2016","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}