{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:11:29Z","timestamp":1792620689551,"version":"4.5.0"},"reference-count":51,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["N5-0247"],"award-info":[{"award-number":["N5-0247"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P2-0076"],"award-info":[{"award-number":["P2-0076"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G073522N"],"award-info":[{"award-number":["G073522N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["12B0E24N"],"award-info":[{"award-number":["12B0E24N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>This study demonstrates that 2 days of intermittent exogenous ketosis at 3,375 m terrestrial altitude does not alter baroreflex sensitivity or heart rate variability but significantly increases pulmonary ventilation under neutral, hypoxic, and hypercapnic conditions, improving oxygenation and lowering carbon dioxide retention. These findings suggest that ketone supplementation may enhance ventilatory acclimatization to high altitude via metabolic acidosis-driven respiratory stimulation, offering a nonpharmacological alternative to typical interventions used to support acclimatization.<\/jats:p>","DOI":"10.1152\/ajpregu.00125.2025","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:02:32Z","timestamp":1752235352000},"page":"R350-R362","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The effects of 2 days of intermittent exogenous ketosis at high altitude on baroreflex sensitivity and ventilation under hypoxic and hypercapnic conditions"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-5626","authenticated-orcid":false,"given":"Benjamin J.","family":"Narang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05060sz93","id-type":"ROR","asserted-by":"publisher"}],"name":"Jo\u017eef Stefan Institute","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1775-7728","authenticated-orcid":false,"given":"Domen","family":"Tominec","sequence":"additional","affiliation":[{"name":"University of Ljubljana","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-6965","authenticated-orcid":false,"given":"Myrthe","family":"Stalmans","sequence":"additional","affiliation":[{"name":"KU Leuven","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-4423","authenticated-orcid":false,"given":"Gr\u00e9goire P.","family":"Millet","sequence":"additional","affiliation":[{"name":"University of Lausanne","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-3075","authenticated-orcid":false,"given":"Chiel","family":"Poff\u00e9","sequence":"additional","affiliation":[{"name":"KU Leuven","place":["Belgium"]},{"name":"Hasselt University","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-3978","authenticated-orcid":false,"given":"Tadej","family":"Debevec","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05060sz93","id-type":"ROR","asserted-by":"publisher"}],"name":"Jo\u017eef Stefan Institute","place":["Slovenia"]},{"name":"University of Ljubljana","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"90","volume":"17","author":"Wyatt FB","year":"2014","journal-title":"J Exerc Physiol Online"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.138883"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01049"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x1998000700002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/JP284579"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1422927"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00364.2020"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12976"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/JP277663"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00305.2019"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.777800"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01072"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.11.5.506"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00190.2024"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00198.2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00097.2025"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003604"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2023.2289961"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa925"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/JP277831"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/JP278673"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/JP285300"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-017-3726-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.04.009"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.094151"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00767"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.12.2.214"},{"key":"B28","first-page":"75","volume-title":"Heart Rate Variability","author":"Kamath MV","year":"1995"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00922"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3758\/bf03193146"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00403"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15857"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-006-0395-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.33192\/smj.v75i10.264037"},{"key":"B36","first-page":"4378","volume":"7","author":"Burtscher M","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01572.2005"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.12.003"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00746.2001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/EP091794"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002467"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00848"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1904.tb01382.x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0132-07.2007"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.263350"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.732120"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827989ec"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-76404-y"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.721673"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79702-7"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00125.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T14:42:55Z","timestamp":1753972975000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00125.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1152\/ajpregu.00125.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00125.2025","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"2025-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}