{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:36:01Z","timestamp":1783485361544,"version":"3.55.0"},"reference-count":52,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100000038","name":"Canadian Government | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-03891"],"award-info":[{"award-number":["RGPIN-2020-03891"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p> We found that local infusion of apocynin or allopurinol improved cutaneous vasodilator responses to passive whole body heating (but not local skin heating) in healthy older adults. These findings indicate that impaired microvascular responses to whole body heating with primary aging are linked to augmented production of reactive oxygen species (ROS) from NADPH oxidase and xanthine oxidase. This study sheds new light on the specific ROS pathways that modulate age-related changes in cutaneous microvascular responses to heating. <\/jats:p>","DOI":"10.1152\/ajpregu.00127.2024","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T18:00:18Z","timestamp":1725645618000},"page":"R543-R552","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulation of cutaneous vasodilation by reactive oxygen species during local and whole body heating in young and older adults"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-7373","authenticated-orcid":false,"given":"Gregory W.","family":"McGarr","sequence":"first","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-7658","authenticated-orcid":false,"given":"Caroline","family":"Li-Maloney","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli E.","family":"King","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina-Marie T.","family":"Janetos","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-8291","authenticated-orcid":false,"given":"Naoto","family":"Fujii","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-6937","authenticated-orcid":false,"given":"Tatsuro","family":"Amano","sequence":"additional","affiliation":[{"name":"Laboratory for Exercise and Environmental Physiology, Faculty of Education, Niigata University, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-6973","authenticated-orcid":false,"given":"Glen P.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.115S2\/ajpheart.00871.2002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00229.2002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1619"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00464.2012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0027-5107(98)00220-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000269183.13937.e8"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00648.2006"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140821"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00481.2013"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01448.2010"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00786.2018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00886.2013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000041431.57222.af"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000012917.74432.66"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000056762.69302.46"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00058.2014"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v054.i10"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01397.2013"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.236398"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00523.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.05.019"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01179.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.153742"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12154"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1441-7"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.142422"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042135"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.77.6.1222"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01187.2009"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13123"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00710.2005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00750.2009"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.4.1323"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.2.605"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.144642"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00082.2008"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00690.2009"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2019.103886"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00714.2015"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.272898"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.03.018"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00515.2003"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr051"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00142.2018"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000037063.90643.0b"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1080\/10623320213638"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.100214"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn185"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00509.2009"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00127.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T14:45:33Z","timestamp":1730904333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00127.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,1]]}},"alternative-id":["10.1152\/ajpregu.00127.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00127.2024","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,1]]},"assertion":[{"value":"2024-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}