{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:21:33Z","timestamp":1782854493552,"version":"3.54.5"},"reference-count":80,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p> Cardiovascular autonomic dysfunction, which is manifested by an impairment of the arterial baroreflex, is prevalent irrespective of etiology and contributes to the increased morbidity and mortality in cirrhotic patients. However, the cellular mechanisms that underlie the cirrhosis-impaired arterial baroreflex remain unknown. In the present study, we examined whether the cirrhosis-impaired arterial baroreflex is attributable to the dysfunction of aortic baroreceptor (AB) neurons. Biliary and nonbiliary cirrhotic rats were generated via common bile duct ligation (CBDL) and intraperitoneal injections of thioacetamide (TAA), respectively. Histological and molecular biological examinations confirmed the development of fibrosis in the livers of both cirrhotic rat models. The heart rate changes during phenylephrine-induced baroreceptor activation indicated that baroreflex sensitivity was blunted in the CBDL and TAA rats. Under the current-clamp mode of the patch-clamp technique, cell excitability was recorded in DiI-labeled AB neurons. The number of action potential discharges in the A- and C-type AB neurons was significantly decreased because of the increased rheobase and threshold potential in the CBDL and TAA rats compared with sham-operated rats. Real-time PCR and Western blotting indicated that the Na<jats:sub>V<\/jats:sub>1.7, Na<jats:sub>V<\/jats:sub>1.8, and Na<jats:sub>V<\/jats:sub>1.9 transcripts and proteins were significantly downregulated in the nodose ganglion neurons from the CBDL and TAA rats compared with the sham-operated rats. Consistent with these molecular data, the tetrodotoxin-sensitive Na<jats:sub>V<\/jats:sub> currents and the tetrodotoxin-resistant Na<jats:sub>V<\/jats:sub> currents were significantly decreased in A- and C-type AB neurons, respectively, from the CBDL and TAA rats compared with the sham-operated rats. Taken together, these findings implicate a key cellular mechanism in the cirrhosis-impaired arterial baroreflex. <\/jats:p>","DOI":"10.1152\/ajpregu.00129.2015","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T03:44:49Z","timestamp":1458186289000},"page":"R1088-R1101","source":"Crossref","is-referenced-by-count":11,"title":["Decreased excitability and voltage-gated sodium currents in aortic baroreceptor neurons contribute to the impairment of arterial baroreflex in cirrhotic rats"],"prefix":"10.1152","volume":"310","author":[{"given":"Choong-Ku","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physiology, Brain Research Group, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Group, Yonsei University Wonju College of Medicine, 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