{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:25:20Z","timestamp":1771554320702,"version":"3.50.1"},"reference-count":99,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-04837"],"award-info":[{"award-number":["RGPIN-2019-04837"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2024-04194"],"award-info":[{"award-number":["RGPIN-2024-04194"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGDAS-2019-00033"],"award-info":[{"award-number":["RGDAS-2019-00033"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["32631"],"award-info":[{"award-number":["32631"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>Using a \u201ctwo-hit\u201d model in mice, we examined the effects of early-life lipopolysaccharide (LPS) administration on steroid regulation in blood and lymphoid organs. Mice received saline or LPS as neonates, and then saline or LPS as adults. Neonatal LPS heightened local glucocorticoid and systemic aldosterone responses to adult LPS treatment in bone marrow, thymus, and spleen. These data highlight the potential role of immunosteroids in developmental programming of immune function and health.<\/jats:p>","DOI":"10.1152\/ajpregu.00135.2025","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:20:56Z","timestamp":1767831656000},"page":"R201-R218","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal lipopolysaccharide administration causes long-term changes in mouse immunosteroids"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0172-939X","authenticated-orcid":false,"given":"Melody","family":"Salehzadeh","sequence":"first","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8851-5335","authenticated-orcid":false,"given":"Anna","family":"Mazurenko","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-8092","authenticated-orcid":false,"given":"Kiran K.","family":"Soma","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1394"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901481"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.04.001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75170"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.014.2009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1077-04.2004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.4.837"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2010.01738.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2266"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22774"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnae008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02611.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqad127"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802886"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.3.E405"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130044"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701328"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00002.2008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.05.003"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1606"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.8.893"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1835"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.15.7104"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1561-6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90196-1"},{"key":"B26","first-page":"156","volume":"15","author":"Johnson E","year":"2001","journal-title":"J Biol Regul Homeost Agent"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab244"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-268508"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3569fje"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(86)80190-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1191\/0960327102ht287oa"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2000.tb01517.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2016.tb00676.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2012.02147.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-144014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090571897"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1748-05.2005"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000191140.87314.ce"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.05.010"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1128\/iai.66.6.2798-2802.1998"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-21-0154"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2019.05.018"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/56106"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13481"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1988.255.4.E525"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2004.11.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22808"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000898"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.17605\/OSF.IO\/67E8R"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-22-0049"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12922"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0386"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19120-0"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00340"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2010.489977"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3922\/j.psns.2014.007"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2023.100711"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0341089"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3090"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac152"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00628-1"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015727"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2012"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac016"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3688-11.2011"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.582614"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.01.004"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.684165"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.048"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1243364"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02749.x"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0159-2"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2016.10.022"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712003105"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1097\/XCE.0000000000000305"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171285"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12754"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0242"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(91)90035-4"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.9.6784"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0030"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14576"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09980"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120718"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1180479"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.131110"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa137"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975858"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo7975"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw331"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001393"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414673200"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32656"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4468"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1293"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.04.004"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1968fje"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23081"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720947199"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00135.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T18:16:58Z","timestamp":1769797018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00135.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpregu.00135.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00135.2025","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}