{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T02:20:40Z","timestamp":1705458040752},"reference-count":54,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:p> Bile duct ligation (BDL), a model of hepatic cirrhosis, is associated with dilutional hyponatremia and inappropriate vasopressin release. \u0394FosB staining was significantly increased in vasopressin and oxytocin magnocellular neurosecretory cells in the supraoptic nucleus (SON) of BDL rats. We tested the role of SON \u0394FosB in fluid retention following BDL by injecting the SON ( n = 10) with 400 nl of an adeno-associated virus (AAV) vector expressing \u0394JunD (a dominant negative construct for \u0394FosB) plus green fluorescent protein (GFP) (AAV-GFP-\u0394JunD). Controls were either noninjected or injected with an AAV vector expressing only GFP. Three weeks after BDL or sham ligation surgery, rats were individually housed in metabolism cages for 1 wk. Average daily water intake was significantly elevated in all BDL rats compared with sham ligated controls. Average daily urine output was significantly greater in AAV-GFP-\u0394JunD-treated BDL rats compared with all other groups. Daily average urine sodium concentration was significantly lower in AAV-GFP-\u0394JunD-treated BDL rats than the other groups, although average daily sodium excretion was not different among the groups. SON expression of \u0394JunD produced a diuresis in BDL rats that may be related to decreased circulating levels of vasopressin or oxytocin. These findings support the view that \u0394FosB expression in SON magnocellular secretory cells contribute to dilutional hyponatremia in BDL rats. <\/jats:p>","DOI":"10.1152\/ajpregu.00142.2012","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T22:05:59Z","timestamp":1337810759000},"page":"R177-R185","source":"Crossref","is-referenced-by-count":14,"title":["\u0394FosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis"],"prefix":"10.1152","volume":"303","author":[{"given":"J. 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