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Exercise is firmly established as an anti-inflammatory therapy that can attenuate or even reverse the process of muscle wasting in cancer cachexia. The interleukin IL-6 is generally considered to be a key player in the development of the microenvironment of malignancy; it promotes tumor growth and metastasis by acting as a bridge between chronic inflammation and cancerous tissue and it also induces skeletal muscle atrophy and protein breakdown. Paradoxically, a beneficial role for IL-6 has also been identified recently, and that is its status as a \u201cfounding member\u201d of the myokine class of proteins. Skeletal muscle is an important source of circulating IL-6 in people who participate in exercise training. IL-6 acts as an anti-inflammatory myokine by inhibiting TNF\u03b1 and improving glucose uptake through the stimulation of AMPK signaling. This review discusses the action of IL-6 in skeletal muscle tissue dysfunction and the role of IL-6 as an \u201cexercise factor\u201d that modulates the immune system. This review also sheds light on the main considerations related to the treatment of muscle wasting in cancer cachexia.<\/jats:p>","DOI":"10.1152\/ajpregu.00147.2019","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T08:14:52Z","timestamp":1576052092000},"page":"R296-R310","source":"Crossref","is-referenced-by-count":79,"title":["Exercise as an anti-inflammatory therapy for cancer cachexia: a focus on interleukin-6 regulation"],"prefix":"10.1152","volume":"318","author":[{"given":"H\u00e9l\u00e8ne N.","family":"Daou","sequence":"first","affiliation":[{"name":"Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102436"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)10090-9"},{"key":"B3","first-page":"932","volume":"62","author":"Angelo LS","year":"2002","journal-title":"Cancer 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