{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:05:29Z","timestamp":1779800729374,"version":"3.53.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"Joint Program Committee-5\/Defense Health Program"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Existing literature suggests cold habituation is capable of cross-adapting submaximal exercise ventilatory, cardiac, and catecholamine responses with normobaric hypoxia. No data exists investigating cold-to-altitude cross adaptation within real-world applicable conditions of hypobaric hypoxia. This investigation suggests that habituation to repeated cold-water immersion does not advantageously cross adapt those subsequently exposed to hypobaric hypoxia.<\/jats:p>","DOI":"10.1152\/ajpregu.00149.2025","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:11:36Z","timestamp":1777050696000},"page":"R652-R663","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-altitude exercise performance and acute mountain sickness unchanged following cold water habituation"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-1423","authenticated-orcid":false,"given":"Afton D.","family":"Seeley","sequence":"first","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-9196","authenticated-orcid":false,"given":"Thomas A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6503-6053","authenticated-orcid":false,"given":"Billie K.","family":"Alba","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5837-6784","authenticated-orcid":false,"given":"Phillip O.","family":"Bodurtha","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7115-8684","authenticated-orcid":false,"given":"Karleigh E.","family":"Bradbury","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4132-5051","authenticated-orcid":false,"given":"Shaun C.","family":"Brazelton","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-6283","authenticated-orcid":false,"given":"Aaron R.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"University of Arkansas for Medical Sciences Northwest","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0033-7711","authenticated-orcid":false,"given":"K. Riley","family":"Connor","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-4399","authenticated-orcid":false,"given":"Gabrielle E. W.","family":"Giersch","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9716-6944","authenticated-orcid":false,"given":"Samantha J.","family":"Goldenstein","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Gonzalez Rojas","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Fry","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-9853","authenticated-orcid":false,"given":"Andrew M.","family":"Greenfield","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-6988","authenticated-orcid":false,"given":"Benjamin J.","family":"Ryan","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-4130","authenticated-orcid":false,"given":"Roy M.","family":"Salgado","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MariaLena A.","family":"Shaw","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]},{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-463X","authenticated-orcid":false,"given":"John W.","family":"Castellani","sequence":"additional","affiliation":[{"name":"US Army Research Institute of Environmental Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.07.018"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094698"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1042\/cs0770581"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2023-0523"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.31.3.183"},{"key":"B6","first-page":"996","volume":"28","author":"Leblanc J","year":"1969","journal-title":"Fed Proc"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.193458"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13728-014-0021-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2025.104216"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2007.1016"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2017.0164"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000255"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827989ec"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.261.4.E419"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.00335.x"},{"key":"B16","volume":"83","author":"Dronjak S","year":"2001","journal-title":"Stress: Neural, Endocrine and Molecular Studies"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(01)02126-6"},{"key":"B18","first-page":"259","volume-title":"Catecholamines and Stress: Recent Advances","author":"Balaz V","year":"1980"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049270"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.43.2.216"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2015.tb00599.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00655.2019"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/JP274596"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3357\/asem.2336.2009"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1995.269.1.R201"},{"key":"B26","first-page":"S159","volume":"12","author":"Reis DJ","year":"1994","journal-title":"J Hypertens Suppl"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200301000-00004"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04471-w"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.4.1151"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.7706"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-22266-5.00004-5"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00149.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:30:33Z","timestamp":1779798633000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00149.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpregu.00149.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00149.2025","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2025-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}