{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:06:13Z","timestamp":1773421573036,"version":"3.50.1"},"reference-count":41,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:p> Whole body heat stress (WBH) results in numerous cardiovascular alterations that ultimately reduce orthostatic tolerance. While impaired carotid baroreflex (CBR) function during WBH has been reported as a potential reason for this decrement, study design considerations may limit interpretation of previous findings. We sought to test the hypothesis that CBR function is unaltered during WBH. CBR function was assessed in 10 healthy male subjects (age: 26 \u00b1 3; height: 185 \u00b1 7 cm; weight: 82 \u00b1 10 kg; BMI: 24 \u00b1 3 kg\/m<jats:sup>2<\/jats:sup>; means \u00b1 SD) using 5-s trials of neck pressure (+45, +30, and +15 Torr) and neck suction (\u221220, \u221240, \u221260, and \u221280 Torr) during normothermia (NT) and passive WBH (\u0394 core temp \u223c1\u00b0C). Analyses of stimulus response curves (four-parameter logistic model) for CBR control of heart rate (CBR-HR) and mean arterial pressure (CBR-MAP), as well as separate two-way ANOVA of the hypotensive and hypertensive stimuli (factor 1: thermal condition, factor 2: chamber pressure), were performed. For CBR-HR, maximal gain was increased during WBH (\u22120.73 \u00b1 0.11) compared with NT (\u22120.39 \u00b1 0.04, mean \u00b1 SE, P = 0.03). In addition, the CBR-HR responding range was increased during WBH (33 \u00b1 5) compared with NT (19 \u00b1 2 bpm, P = 0.03). Separate analysis of hypertensive stimulation revealed enhanced HR responses during WBH at \u221240, \u221260, and \u221280 Torr (condition \u00d7 chamber pressure interaction, P = 0.049) compared with NT. For CBR-MAP, both logistic analysis and separate two-way ANOVA revealed no differences during WBH. Therefore, in response to passive WBH, CBR control of heart rate (enhanced) and arterial pressure (no change) is well preserved. <\/jats:p>","DOI":"10.1152\/ajpregu.00152.2016","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T02:49:28Z","timestamp":1470278968000},"page":"R735-R741","source":"Crossref","is-referenced-by-count":10,"title":["Carotid baroreflex control of heart rate is enhanced, while control of mean arterial pressure is preserved during whole body heat stress in young healthy men"],"prefix":"10.1152","volume":"311","author":[{"given":"Davor","family":"Krnjajic","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Texas, Arlington, Arlington, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin R.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Texas, Arlington, Arlington, 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