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However, the blood flow response to exercise in patients with PAD actually remains equivocal. Therefore, eight patients with PAD and eight healthy controls completed 3 min of plantar flexion exercise at both an absolute work rate (WR) (2.7 W, to evaluate blood flow) and a relative intensity (40%WR<jats:sub>max<\/jats:sub>, to evaluate MAP). The exercise-induced change in popliteal artery blood flow (BF, Ultrasound Doppler), MAP (Finapress), and vascular conductance (VC) were quantified. In addition, resting markers of inflammation and oxidative stress were measured in plasma and muscle biopsies. Exercise-induced \u0394BF, assessed at 2.7 W, was lower in PAD compared with controls (PAD: 251\u2009\u00b1\u2009150 vs. Controls: 545\u2009\u00b1\u2009187 mL\/min, P &lt; 0.001), whereas \u0394MAP, assessed at 40%WR<jats:sub>max<\/jats:sub>, was greater for PAD (PAD: 23\u2009\u00b1\u200914 vs. Controls: 11\u2009\u00b1\u20096 mmHg, P = 0.028). The exercise-induced \u0394VC was lower for PAD during both the absolute WR (PAD: 1.9\u2009\u00b1\u20091.6 vs. Controls: 4.7\u2009\u00b1\u20091.9 mL\/min\/mmHg) and relative intensity exercise (PAD: 1.9\u2009\u00b1\u20091.8 vs. Controls: 5.0\u2009\u00b1\u20092.2 mL\/min\/mmHg) trials (both, P &lt; 0.01). Inflammatory and oxidative stress markers, including plasma interleukin-6 and muscle protein carbonyls, were elevated in PAD (both, P &lt; 0.05), and significantly correlated with the hemodynamic changes during exercise ( r = \u22120.57 to \u22120.78, P &lt; 0.05). Thus, despite an exaggerated \u0394MAP response, patients with PAD exhibit an impaired exercise-induced \u0394BF and \u0394VC, and both inflammation and oxidative stress likely play a role in this attenuated hemodynamic response. <\/jats:p>","DOI":"10.1152\/ajpregu.00159.2022","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T11:44:25Z","timestamp":1664192665000},"page":"R710-R719","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Impaired hemodynamic response to exercise in patients with peripheral artery disease: evidence of a link to inflammation and oxidative stress"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5959-4139","authenticated-orcid":false,"given":"Jesse C.","family":"Craig","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, Utah"},{"name":"Geriatric Research, 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