{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:10:49Z","timestamp":1742379049443,"version":"3.37.3"},"reference-count":55,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-03891"],"award-info":[{"award-number":["RGPIN-2020-03891"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008572","name":"Human and Environmental Physiology Research Unit, University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p> Metaboreflex activation augments sweating during mild-to-moderate hyperthermia in euhydrated (isosmotic isovolemic) individuals. Recent work indicates that extracellular hyperosmolality may augment metaboreflex-mediated elevations in sympathetic nervous activity. Our primary objective was, therefore, to test the hypothesis that extracellular hyperosmolality would exacerbate metaboreflex-mediated increases in sweat rate. On two separate occasions, 12 young men [means (SD): 25 (5) yr] received a 90-min intravenous infusion of either 0.9% saline (isosmotic condition, ISO) or 3.0% saline (hyperosmotic condition, HYP), resulting in a postinfusion serum osmolality of 290 (3) and 301 (7) mosmol\/kgH<jats:sub>2<\/jats:sub>O, respectively. A whole body water perfusion suit was then used to increase esophageal temperature by 0.8\u00b0C above resting. Participants then performed a metaboreflex activation protocol consisting of 90-s isometric handgrip exercise (40% of their predetermined maximum voluntary contraction), followed by 150 s of brachial occlusion (trapping produced metabolites within the limb). Metaboreflex-induced sweating was quantified as the change in global sweat rate (from preisometric handgrip exercise to brachial occlusion), estimated as the surface area-weighted average of local sweat rate on the abdomen, axilla, chest, bicep, quadriceps, and calf, measured using ventilated capsules (3.8 cm<jats:sup>2<\/jats:sup>). We also explored whether this response differed between body regions. The change in global sweat rate due to metaboreflex activation was significantly greater in HYP compared with ISO (0.03 mg\/min\/cm<jats:sup>2<\/jats:sup> [95% confidence interval: 0.00, 0.06]; P = 0.047), but was not modulated by body region (site \u00d7 condition interaction: P = 0.679). These findings indicate that extracellular hyperosmolality augments metaboreflex-induced increases in global sweat rate, with no evidence for region-specific differences. <\/jats:p>","DOI":"10.1152\/ajpregu.00161.2021","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T13:00:30Z","timestamp":1637154030000},"page":"R1-R13","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of extracellular hyperosmolality on sweat rate during metaboreflex activation in passively heated young men"],"prefix":"10.1152","volume":"322","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-6796","authenticated-orcid":true,"given":"Maura M.","family":"Rutherford","sequence":"first","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley P.","family":"Akerman","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Meade","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5000","authenticated-orcid":true,"given":"Sean R.","family":"Notley","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison D.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-6973","authenticated-orcid":true,"given":"Glen P.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"211","volume-title":"Handbook of Clinical Neurology","volume":"156","author":"Gagnon D","year":"2018"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2741\/3620"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2741\/s94"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1937.sp003485"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.591ac.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00605.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00212.2011"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00463.2011"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199206000-00008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.1.R197"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00242.2009"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00411.2011"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.226"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/JP271497"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/JP280132"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093280.40118.30"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.461"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019548"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00559.2017"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00813.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.1.80"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.6.828"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00810.2002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00515.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1113\/EP085908"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/b978-1-4832-3110-5.50011-x"},{"key":"B30","first-page":"1","volume-title":"Certified Fitness Appraiser Resource Manual","author":"Canadian Society for Exercise Physiology","year":"1986"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00523.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2019.03.008"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/2046-7648-2-4"},{"volume-title":"Ergonomics-Evaluation of Thermal Strain by Physiological Measurements","year":"1992","author":"International Organization of Standards","key":"B34"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.23.12.624"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00359.2003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00250.2009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/EP089074"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238559"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1744-8"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.5.1590"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00283.2017"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80131-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010442"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00120.2014"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.066498"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2017-0482"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-018-4004-y"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001877"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.245"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00562.2010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1113\/EP089464"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1985.249.2.R186"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1893"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-004-1303-2"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e31817be928"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00161.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T18:06:51Z","timestamp":1640196411000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00161.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,1]]}},"alternative-id":["10.1152\/ajpregu.00161.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00161.2021","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"type":"print","value":"0363-6119"},{"type":"electronic","value":"1522-1490"}],"subject":[],"published":{"date-parts":[[2022,1,1]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}