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We examined effects of caloric restriction (CR) on growth and metabolic status in LPO and normal protein offspring (NPO) randomized to AL or CR diets from weaning. CR transiently reduced growth in both LPO and NPO, delaying recovery in female LPO-CR. Over 7.5\u201312.5 weeks, linear growth rates in LPO-CR were slower than LPO-AL ( P\u2009&lt; 0.001) but exceeded NPO-AL; body weight growth rates fell but were lower in LPO-CR versus NPO-CR. Linear acceleration ceased after 12 weeks. At 16 weeks, percent catch-up in LPO-CR was reduced versus LPO-AL ( P\u2009&lt; 0.001). Plasma growth hormone was low in LPO ( P\u2009&lt; 0.02). CR normalized fat deposition rate, yet adiponectin mRNA remained low in LPO-CR ( P\u2009&lt; 0.001); plasma adiponectin was low in all LPO-AL and in female LPO-CR. Insulin sensitivity improved during CR. We conclude that in LPO: 1) CR delays onset of, but does not abolish, accelerated linear growth, despite low growth hormone; 2) CR yields stunting via delayed onset, plus a finite window for linear growth acceleration; 3) MPR lowers adiponectin mRNA independently of growth, adiposity, or adipocyte size; and 4) MPR reduces circulating adiponectin in LPO-AL and female LPO-CR, potentially enhancing cardiometabolic risk.<\/jats:p>","DOI":"10.1152\/ajpregu.00162.2017","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T18:15:31Z","timestamp":1529518531000},"page":"R354-R368","source":"Crossref","is-referenced-by-count":3,"title":["Effects of postweaning calorie restriction on accelerated growth and adiponectin in nutritionally programmed microswine offspring"],"prefix":"10.1152","volume":"315","author":[{"given":"Elizabeth A.","family":"DuPriest","sequence":"first","affiliation":[{"name":"Department of Medicine, Oregon Health &amp; Science University, 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