{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:24:59Z","timestamp":1759937099048},"reference-count":46,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p> Caloric deprivation inhibits reproduction, including copulatory behaviors, in female mammals. Decreases in metabolic fuel availability are detected in the hindbrain, and this information is relayed to the forebrain circuits controlling estrous behavior by neuropeptide Y (NPY) projections. In the forebrain, the nutritional inhibition of estrous behavior appears to be mediated by corticotropin-releasing factor (CRF) or urocortin-signaling systems. Intracerebroventricular (ICV) infusion of the CRF antagonist, astressin, prevents the suppression of lordosis by food deprivation and by NPY treatment in Syrian hamsters. These experiments sought to determine which CRF receptor type(s) is involved. ICV infusion of the CRF receptor subtype CRFR2-selective agonists urocortin 2 and 3 (UCN2, UCN3) inhibited sexual receptivity in hormone-primed, ovariectomized hamsters. Furthermore, the CRFR2-selective antagonist, astressin 2B, prevented the inhibition of estrous behavior by UCN2 and by NPY, consistent with a role for CRFR2. On the other hand, astressin 2B did not prevent the inhibition of behavior induced by 48-h food deprivation or ICV administration of CRF, a mixed CRFR1 and CRFR2 agonist, suggesting that activation of CRFR1 signaling is sufficient to inhibit sexual receptivity in hamsters. Although administration of CRFR1-selective antagonists (NBI-27914 and CP-154,526) failed to reverse the inhibition of receptivity by CRF treatment, we could not confirm their biological effectiveness in hamsters. The most parsimonious interpretation of these findings is that, although NPY inhibits estrous behavior via downstream CRFR2 signaling, food deprivation may exert its inhibition via both CRFR1 and CRFR2 and that redundant neuropeptide systems may be involved. <\/jats:p>","DOI":"10.1152\/ajpregu.00168.2005","type":"journal-article","created":{"date-parts":[[2005,4,14]],"date-time":"2005-04-14T20:33:26Z","timestamp":1113510806000},"page":"R418-R423","source":"Crossref","is-referenced-by-count":14,"title":["Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters"],"prefix":"10.1152","volume":"289","author":[{"given":"Patricia L.","family":"Seymour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Dettloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George N.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02926.2002"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0091"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121410"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(00)00153-4"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-03-01142.2000"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991220)415:3<285::AID-CNE1>3.0.CO;2-0"},{"key":"R7","unstructured":"Bronson FH. 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