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However, it is not fully elucidated if mean arterial pressure (MAP) leads to this physiological entrainment independently, or if heart rate (HR) and\/or the partial pressure of carbon dioxide (Pco<jats:sub>2<\/jats:sub>) also have contributing influences. A 2:1 control-to-case model was used in the present investigation [participant number ( n) = 40; n = 16 age-matched (AM); n = 16 donor control (DM); n = 8 heart transplant recipients (HTRs)]. The latter group was used to mechanistically isolate the extent to which HR influences the cerebral pressure-flow relationship. Participants completed 5 min of squat-stand maneuvers at 0.05 Hz (10 s) and 0.10 Hz (5 s). Linear transfer function analysis (TFA) examined the relationship between different physiological inputs (i.e., MAP, HR, and Pco<jats:sub>2<\/jats:sub>) and output [cerebral blood velocity (CBV)] during SSM; and cardiac baroreceptor sensitivity (BRS). Compared with DM, cardiac BRS was reduced in AM ( P &lt; 0.001), which was further reduced in HTR ( P &lt; 0.045). In addition, during the SSM, HR was elevated in HTR compared with both control groups ( P &lt; 0.001), but all groups had near-maximal coherence metrics \u22650.98 at 0.05 Hz and \u22650.99 at 0.10 Hz ( P \u2265 0.399). In contrast, the mean HR-CBV\/Pco<jats:sub>2<\/jats:sub>-CBV relationships ranged from 0.38 (HTR) to 0.81 (DM). Despite near abolishment of BRS and blunted HR following heart transplantation, long-term HTR exhibited near-maximal coherence within the MAP-CBV relationship, comparable with AM and DM. Therefore, these results show that the augmented coherence with SSM is driven by blood pressure, whereas elevations in TFA coherence as a result of HR contribution are likely correlational in nature. <\/jats:p>","DOI":"10.1152\/ajpregu.00177.2021","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T12:00:55Z","timestamp":1635940855000},"page":"R925-R937","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term heart transplant recipients: heart rate-related effects on augmented transfer function coherence during repeated squat-stand maneuvers in males"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-5793","authenticated-orcid":true,"given":"Joel S.","family":"Burma","sequence":"first","affiliation":[{"name":"Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada"},{"name":"Sport 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