{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:53:39Z","timestamp":1778943219914,"version":"3.51.4"},"reference-count":25,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>The present study was undertaken to investigate the origin of cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactive (irCART) fibers observed in the nucleus of the solitary tract (NTS) and assess the role of CART peptide on phenylephrine (PE)-induced baroreflex. Immunohistochemical and retrograde tract-tracing studies showed that some of the irCART fibers observed in the NTS may have their cell bodies in the nodose ganglia. In urethane-anesthetized rats, intracisternal or bilateral intra-NTS microinjection of the CART peptide fragment 55-102 (0.1-3 nmol), referred to herein as CARTp, consistently and dose dependently attenuated PE-induced bradycardia. CARTp, in the doses used here, caused no significant changes of resting blood pressure or heart rate. Bilateral intra-NTS injections of CART antibody (1:500) potentiated PE-induced bradycardia. Injections of saline, normal rabbit serum, or concomitant injection of CARTp and CART antiserum into the NTS caused no significant changes of PE-induced baroreflex. The result suggests that endogenously released CARTp from primary afferents or exogenously administered CARTp modulates PE-induced baroreflex.<\/jats:p>","DOI":"10.1152\/ajpregu.00183.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:32:56Z","timestamp":1425414776000},"page":"R1496-R1503","source":"Crossref","is-referenced-by-count":23,"title":["Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats"],"prefix":"10.1152","volume":"285","author":[{"given":"Phouangmala","family":"Scruggs","sequence":"first","affiliation":[{"name":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siok L.","family":"Dun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nae J.","family":"Dun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.6.R1862"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.56.030194.000521"},{"key":"REF3","unstructured":"Broberger C, Holmberg K, Kuhar MJ, and Hokfelt T.Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: a putative mediator of cholecystokinin-induced satiety.Proc Natl Acad Sci USA93: 13506-13511, 1999."},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00212-3"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(01)00226-9"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00550-2"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-03-02471.1995"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00935-6"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00267-X"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(01)00147-8"},{"key":"REF11","doi-asserted-by":"crossref","unstructured":"Ferrario CM, Barnes KL, and Bohonek S.Neurogenic hypertension produced by lesions of the nucleus tractus solitarii alone or with sinoaortic denervation in the dog.Hypertension396: 112-118, 1981.","DOI":"10.1161\/01.HYP.3.6_Pt_2.II-112"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00806.2000"},{"key":"REF13","doi-asserted-by":"crossref","unstructured":"Kimmel HL, Gong W, Vechia SD, Hunter RG, and Kuhar MJ.Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference.J Pharmacol Exp Ther294: 784-792, 2000.","DOI":"10.1016\/S0022-3565(24)39135-9"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<115::AID-CNE10>3.0.CO;2-X"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1038\/29993"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(19990901)33:3<163::AID-SYN1>3.0.CO;2-T"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.092968"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00374-5"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.8.7588"},{"key":"REF21","unstructured":"Paxinos Gand Watson C.The Rat Brain in Stereotaxic Coordinates(4th ed.). 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