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Thus, the present study sought to evaluate the efficacy of an acute over-the-counter AO cocktail (600 mg \u03b1-lipoic acid, 1,000 mg vitamin C, and 600 IU vitamin E) to mitigate inflammation and oxidative stress, and subsequently improve nitric oxide (NO) bioavailability and vascular function, in patients with HFpEF. Flow-mediated dilation (FMD) and reactive hyperemia (RH) were evaluated to assess conduit vessel and microvascular function, respectively, 90 min after administration of either placebo (PL) or AO in 16 patients with HFpEF (73\u2009\u00b1\u200910 yr, EF 54\u201370%) using a double-blind, crossover design. Circulating biomarkers of inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde and protein carbonyl), free radical concentration (EPR spectroscopy), antioxidant capacity, ascorbate and NO bioavailability (plasma nitrate, [Formula: see text], and nitrite, [Formula: see text]) were also assessed. FMD improved following AO administration (PL: 3.49\u2009\u00b1\u20090.7%, AO: 5.83\u2009\u00b1\u20091.0%), whereas RH responses were similar between conditions (PL: 428\u2009\u00b1\u200951 mL, AO: 425\u2009\u00b1\u200951 mL). AO administration decreased CRP (PL: 4,429\u2009\u00b1\u2009705 ng\/mL, AO: 3,664\u2009\u00b1\u2009520 ng\/mL) and increased ascorbate (PL: 30.0\u2009\u00b1\u20092.9 \u00b5g\/mL, AO: 45.1\u2009\u00b1\u20093.7 \u00b5g\/mL) and [Formula: see text] (PL: 182\u2009\u00b1\u200921 nM, AO: 213\u2009\u00b1\u200924 nM) but did not affect other biomarkers. Together, these data suggest that acute AO administration can exert anti-inflammatory effects and improve conduit artery vasodilation, but not microvascular function, in patients with HFpEF.<\/jats:p>","DOI":"10.1152\/ajpregu.00184.2019","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T11:57:23Z","timestamp":1567598243000},"page":"R607-R614","source":"Crossref","is-referenced-by-count":22,"title":["Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction"],"prefix":"10.1152","volume":"317","author":[{"given":"Stephen M.","family":"Ratchford","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, George E. 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