{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:43Z","timestamp":1740139123282,"version":"3.37.3"},"reference-count":57,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000006","name":"DOD | US Navy | Office of Naval Research","doi-asserted-by":"publisher","award":["N000141612954"],"award-info":[{"award-number":["N000141612954"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001412"],"award-info":[{"award-number":["UL1TR001412"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K12HL138052"],"award-info":[{"award-number":["K12HL138052"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:p> Tonic carotid body (CB) activity is reduced during exposure to cold and hyperoxia. We tested the hypotheses that cold water diving lowers CB chemosensitivity and augments CO<jats:sub>2<\/jats:sub> retention more than thermoneutral diving. Thirteen subjects [age: 26\u2009\u00b1\u20094 yr; body mass index (BMI): 26\u2009\u00b1\u20092 kg\/m<jats:sup>2<\/jats:sup>) completed two 4-h head-out water immersion protocols in a hyperbaric chamber (1.6 ATA) in cold (15\u00b0C) and thermoneutral (25\u00b0C) water. CB chemosensitivity was assessed with brief hypercapnic ventilatory response ([Formula: see text]) and hypoxic ventilatory response ([Formula: see text]) tests before dive, 80 and 160 min into the dive (D80 and D160, respectively), and immediately after and 60 min after dive. Data are reported as an absolute mean (SD) change from predive. End-tidal CO<jats:sub>2<\/jats:sub> pressure increased during both the thermoneutral water dive [D160: +2 (3) mmHg; P = 0.02] and the cold water dive [D160: +1 (2) mmHg; P = 0.03]. Ventilation increased during the cold water dive [D80: 4.13 (4.38) and D160: 7.75 (5.23) L\u00b7min<jats:sup>\u22121<\/jats:sup>; both P &lt; 0.01] and was greater than the thermoneutral water dive at both time points (both P &lt; 0.01). [Formula: see text] was unchanged during the dive ( P = 0.24) and was not different between conditions ( P = 0.23). [Formula: see text] decreased during the thermoneutral water dive [D80: \u22123.45 (3.61) and D160: \u22122.76 (4.04) L\u00b7min\u00b7mmHg<jats:sup>\u22121<\/jats:sup>; P &lt; 0.01 and P = 0.03, respectively] but not the cold water dive. However, [Formula: see text] was not different between conditions ( P = 0.17). In conclusion, CB chemosensitivity was not attenuated during the cold stress diving condition and does not appear to contribute to changes in ventilation or CO<jats:sub>2<\/jats:sub> retention. <\/jats:p>","DOI":"10.1152\/ajpregu.00202.2020","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T19:58:27Z","timestamp":1623873507000},"page":"R197-R207","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Carotid body chemosensitivity is not attenuated during cold water diving"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-7208","authenticated-orcid":true,"given":"Hayden W.","family":"Hess","sequence":"first","affiliation":[{"name":"Center for Research and Education in Special Environments, University at Buffalo, Buffalo, New York"},{"name":"Department of Kinesiology, School of Public Health, Indiana University, Bloomington, 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