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We found that 48 h without food (24 h beyond normal 24-h fasting period) produced no significant change in Hcrt-1 levels nor did feeding after the deprivation. In contrast, 24 h of sleep deprivation produced on average a 70% increase in Hcrt-1 level compared with baseline levels. The amount of increase was correlated with the level of motor activity during the sleep-deprivation procedure. A 2-h period of exercise in the same dogs produced a 57% increase in Hcrt-1 levels relative to quiet waking levels, with the magnitude of the increase being highly correlated with the level of motor activity. The strong correlation between motor activity and Hcrt-1 release may explain some of the previously reported behavioral, physiological, and pathological phenomena ascribed to the Hcrt system.<\/jats:p>","DOI":"10.1152\/ajpregu.00207.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:26:18Z","timestamp":1425414378000},"page":"R1079-R1086","source":"Crossref","is-referenced-by-count":106,"title":["Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement"],"prefix":"10.1152","volume":"283","author":[{"given":"M.-F.","family":"Wu","sequence":"first","affiliation":[{"name":"Neurobiology Research (151A3), Veterans Affairs Greater Los Angeles Healthcare System-Sepulveda, North Hills 91343; and"},{"name":"Department of Psychiatry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"John","sequence":"additional","affiliation":[{"name":"Neurobiology Research (151A3), Veterans Affairs Greater Los Angeles Healthcare System-Sepulveda, North Hills 91343; and"},{"name":"Department of Psychiatry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maidment","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and"},{"name":"Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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