{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:02:46Z","timestamp":1777323766886,"version":"3.51.4"},"reference-count":50,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Dietary sodium restriction coupled with axotomy of the rat chorda tympani nerve (CTX) results in selectively attenuated taste responses to sodium salts in the contralateral, intact chorda tympani nerve. Converging evidence indicates that sodium deficiency also diminishes the activated macrophage response to injury on both the sectioned and contralateral, intact sides of the tongue. Because a sodium-restricted diet causes a robust increase in circulating aldosterone, we tested the hypothesis that changes in neurophysiological and immune responses contralateral to the CTX could be mimicked by aldosterone administration instead of the low-sodium diet. Taste responses in rats with CTX and supplemental aldosterone for 4\u20136 days were similar to rats with CTX and dietary sodium restriction. Responses to sodium salts were as much as 50% lower compared with sham-operated and vehicle-supplemented rats. The group-related functional differences were eliminated with lingual application of amiloride, suggesting that a major transduction pathway affected was through epithelial sodium channels. Consistent with the functional results, few macrophages were observed on either side of the tongue in rats with CTX and aldosterone. In contrast, macrophages were elevated on both sides of the tongue in rats with CTX and the vehicle. These results show that sodium deficiency or administration of aldosterone suppresses the immune response to neural injury, resulting in attenuation of peripheral gustatory function. They also show a potential key link among downstream consequences of sodium imbalance, taste function, and immune activity.<\/jats:p>","DOI":"10.1152\/ajpregu.00219.2009","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T02:06:08Z","timestamp":1250129168000},"page":"R1103-R1110","source":"Crossref","is-referenced-by-count":11,"title":["Attenuation of peripheral salt taste responses and local immune function contralateral to gustatory nerve injury: effects of aldosterone"],"prefix":"10.1152","volume":"297","author":[{"given":"Nick A.","family":"Guagliardo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie Nicole","family":"West","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine\/Developmental Neurobiology and Department of Neurology, Medical College of Georgia, Augusta, Georgia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynnette P.","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine\/Developmental Neurobiology and Department of Neurology, Medical College of Georgia, Augusta, Georgia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Virginia, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.2.975"},{"key":"B2","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1016\/S0021-9258(18)41965-5","volume":"267","author":"Asher C","year":"1992","journal-title":"J Biol Chem"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.2.C605"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.4.722"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095489"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20438"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21128"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720406"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720405"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.73.5.569"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00422-X"},{"key":"B12","unstructured":"Denton DA. 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