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An initial study was conducted to determine the time course of effects of fluoxetine (Flu) administration on baroreflex control of lumbar sympathetic nerve activity (LSNA) in conscious, chronically instrumented rats. Animals received either vehicle (Veh, sterile water) or 10 mg\/kg Flu for 1, 4, or 16 days of treatment. Data indicate that while 1-day and 16-day Flu administration did not affect baroreflex function, baroreflex control of LSNA was enhanced after 4-day (short term) Flu administration. HU rats were then treated with Flu for 4 days and compared with HU rats receiving Veh and to casted control rats maintained in the normal posture that received either Veh or short-term Flu treatment. Similar to pilot data, short-term Flu treatment enhanced baroreflex control of LSNA in both HU rats and control rats. These data taken together indicate that baroreflex control of sympathetic nervous system activity is a possible mechanism responsible for the successful treatment of orthostatic intolerance with Flu.<\/jats:p>","DOI":"10.1152\/ajpregu.00223.2002","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T23:25:51Z","timestamp":1075937151000},"page":"R584-R590","source":"Crossref","is-referenced-by-count":18,"title":["Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading"],"prefix":"10.1152","volume":"286","author":[{"given":"Julia A.","family":"Moffitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Kim","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00202-5"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1146-7"},{"key":"REF3","doi-asserted-by":"crossref","unstructured":"Blomqvist CGand Stone HL.Cardiovascular adjustments to gravitational stress. 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