{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:38:20Z","timestamp":1773985100489,"version":"3.50.1"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p> Chronic consumption of ethanol in adult rats and humans leads to reduced AVP-producing neurons, and prenatal ethanol (PE) exposure has been reported to cause changes in the morphology of AVP-producing cells in the suprachiasmatic nucleus of young rats. The present studies further characterize the effects of PE exposure on AVP in the young adult rat, its hypothalamic synthesis, pituitary storage, and osmotically stimulated release. Pregnant rats were fed a liquid diet with 35% of the calories from ethanol or a control liquid diet for days 7\u201322 of pregnancy. Water consumption and urine excretion rate were measured in the offspring at 60\u201368 days of age. Subsequently, the offspring were infused with 5% NaCl at 0.05 ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> with plasma samples taken before and at three 40-min intervals during infusion for measurement of AVP and osmolality. Urine output and water intake were \u223c20% greater in PE-exposed rats than in rats with no PE exposure, and female rats had a greater water intake than males. The relationship between plasma osmolality and AVP in PE-exposed rats was parallel to, but shifted to the right of, the control rats, indicating an increase in osmotic threshold for AVP release. Pituitary AVP was reduced by 13% and hypothalamic AVP mRNA content was reduced by 35% in PE-exposed rats. Our data suggest that PE exposure can cause a permanent condition of a mild partial central diabetes insipidus. <\/jats:p>","DOI":"10.1152\/ajpregu.00223.2003","type":"journal-article","created":{"date-parts":[[2004,5,17]],"date-time":"2004-05-17T20:33:53Z","timestamp":1084826033000},"page":"R277-R283","source":"Crossref","is-referenced-by-count":16,"title":["Prenatal exposure to ethanol causes partial diabetes insipidus in adult rats"],"prefix":"10.1152","volume":"287","author":[{"given":"Daniel S.","family":"Knee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aileen K.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine F. T.","family":"Uyehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Claybaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009366"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1159\/000240510"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858439"},{"key":"R4","unstructured":"Bohus B, Borrell J, Koolhaas JM, Nyakas C, Buwalda B, Compaan JC, and Roozendaal B. The neuohypophysial peptides, learning, and memory processing. In: The Neurohyophysis: A Window on Brain Function, edited by North WG, Moses AM, and Share L. New York: NY Academy of Science, 1993, p. 285\u2013299."},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0950403"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R966"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb01368.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1978.235.4.H361"},{"key":"R9","unstructured":"Dorland WAN. (Editor). Dorland's Illustrated Medical Dictionary (28th ed.). Philadelphia, PA: Saunder, 1988."},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(89)90018-9"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02297.x"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02295.x"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00577-3"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00943.x"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-3-641"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04023.x"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197907000-00009"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0890"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90363-K"},{"key":"R20","unstructured":"Maier SE, Miller JA, Blackwell JM, and West JR. Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development. Alcohol Clin Exp Res 23: 726\u2013734, 1999."},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(00)00133-6"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"McGivern RF, Ervin MG, McGeary J, Somes C, and Handa RJ. Prenatal ethanol exposure induces a sexually dimorphic effect on daily water consumption in prepubertal and adult rats. Alcohol 22: 868\u2013875 1998.","DOI":"10.1111\/j.1530-0277.1998.tb03881.x"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.29.121"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.1.R158"},{"key":"R25","unstructured":"Raff H. Interactions between neurohypophysial hormones and the ACTH-adrenocortical axis In: The Neurohypophysis: A Window on Brain Function, edited by North WG, Moses AM, and Share L. New York: NY Academy of Science, 1993, vol. 689, p. 411\u2013425 (Annals NY Acad Sci Ser)."},{"key":"R26","unstructured":"Rojas-Castaneda J, Rojas P, Vigueras RM, Reyes G, and Rajas C. Prenatal ethanol exposure results in morphometrical alterations in immunoreactive neurons to vasopressin in the suprachiasmatic nucleus of young rats. Proc West Pharmacol Soc 43: 83\u201385, 2000."},{"key":"R27","unstructured":"Rojas-Castaneda J, Vigueras RM, Sicilia G, Reyes G, Cintra L, and Aguilar-Roblero R. Effects of acute prenatal ethanol exposure on immunoreactive vasopressin and vasactive intestinal polypeptide cells in the suprachiasmatic nucleus of the rat. Proc West Pharmacol Soc 41: 55\u201356, 1998."},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90035-N"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00263-1"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-4-2040"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.265.4.R943"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.265.6.R1284"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00223.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T11:01:15Z","timestamp":1567940475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00223.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1152\/ajpregu.00223.2003"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00223.2003","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}