{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:46:26Z","timestamp":1763563586224,"version":"3.30.2"},"reference-count":45,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>The effects of lowering body temperature (T<jats:sub>b<\/jats:sub>) on metabolic rate, ventilation, and the strength of the Hering-Bre\u00fcer expiratory promoting reflex (HB reflex; determined from an inhibitory ratio calculated from volumetric measurements of the respiratory rhythm) were examined in 18-day-old ectothermic pouch young of the tammar wallaby during normoxia or hypoxia (10% O<jats:sub>2<\/jats:sub>). Hypoxia and hypothermia, either singularly or combined, depressed metabolic rate. At all T<jats:sub>b<\/jats:sub>, the hypoxic hyperventilation was associated with a significant hyperpnea. At pouch T<jats:sub>b<\/jats:sub>(36.5\u00b0C) during normoxia, inflation of the lungs with -5 or -10 cmH<jats:sub>2<\/jats:sub>O extrathoracic pressure induced a significant HB reflex. Exposure to cold reduced the strength of the reflex, almost abolishing it at 28\u00b0C. For T<jats:sub>b<\/jats:sub>above 28\u00b0C, the reflex in hypoxia was always less than the corresponding normoxic value. Taken in context with the changes in metabolic state that occurred, these data in the ectothermic marsupial newborn suggest that the decline in the HB reflex during moderate hypothermia is the result of a direct effect of T<jats:sub>b<\/jats:sub>on vagal mechanisms rather than a temperature-driven decline in metabolic rate that should have acted to strengthen the HB reflex. Therefore, it seems that inputs inhibitory to breathing are more negatively affected during cold than those inputs that are excitatory.<\/jats:p>","DOI":"10.1152\/ajpregu.00225.2003","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T20:08:06Z","timestamp":1081282086000},"page":"R857-R864","source":"Crossref","is-referenced-by-count":7,"title":["Hypothermia and hypoxia inhibit the Hering-Bre\u00fcer reflex in the marsupial newborn"],"prefix":"10.1152","volume":"286","author":[{"given":"P. M.","family":"MacFarlane","sequence":"first","affiliation":[{"name":"Adaptational and Evolutionary Respiratory Physiology Laboratory, Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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