{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:40:18Z","timestamp":1790941218989,"version":"4.1.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p> Acute administration of peptide YY(3-36) [PYY(3-36)] results in a reduction in food intake in several different vertebrates. However, long-term continuous administration of PYY(3-36) causes only a transient reduction in food intake, thus potentially limiting its therapeutic efficacy. We hypothesized that a fall in leptin levels associated with reduced food intake could contribute to the transient anorectic effects of continuous PYY(3-36) infusion and thus that leptin replacement might prolong the anorectic effects of PYY(3-36). Seven-day administration of 100 \u03bcg\u00b7kg body wt<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> PYY(3-36) using osmotic minipumps caused a significant reduction in food intake of ad libitum-fed rats, but only for the first 2 days postimplantation. Circulating levels of leptin were reduced 1 day following continuous infusion of PYY(3-36), and combined leptin infusion at a dose of leptin that had no anorectic effects on its own (100 \u03bcg\u00b7kg body wt<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) prolonged the anorectic actions of PYY(3-36) in ad libitum-fed rats for up to 6 days postimplantation and yielded reduced weight gain compared with either peptide alone. The inhibitory effects of 100 \u03bcg\u00b7kg body wt<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> PYY(3-36) on food intake were absent in rats refed after a 24-h fast and substantially reduced at a dose of 1,000 \u03bcg\u00b7kg body wt<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> PYY(3-36). Leptin replacement was unable to recover the anorectic effects of PYY(3-36) in fasted rats. Our results suggest that an acute fall in leptin levels is not solely responsible for limiting duration of action of chronic PYY(3-36) infusion, yet chronic coadministration of a subanorectic dose of leptin can extend the anorectic effects of PYY(3-36). <\/jats:p>","DOI":"10.1152\/ajpregu.00234.2007","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T01:38:15Z","timestamp":1208396295000},"page":"R51-R58","source":"Crossref","is-referenced-by-count":37,"title":["Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats"],"prefix":"10.1152","volume":"295","author":[{"given":"Suraj","family":"Unniappan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Kieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.03.011"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.02.065"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803137"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0518"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.195"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90211-2"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109951"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00350-0"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/nature00887"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030204"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.001"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/nature06212"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0237-0"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1038\/430165a"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-200053522"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306931101"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0041-2"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00376.2004"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1138"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00674.2005"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.08.001"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Degen L, Oesch S, Casanova M, Graf S, Ketterer S, Drewe J, Beglinger C. 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