{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:00:57Z","timestamp":1789790457323,"version":"4.0.1"},"reference-count":36,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> Central administration of a single dose of prolactin-releasing peptide (PrRP) causes a reduction in both fast-induced and nocturnal food intake and body weight gain. The aim of this study was to examine the effect of repeated administration of PrRP on energy homeostasis, including a measure of the expression of the mitochondrial uncoupling protein-1 (UCP-1) in brown adipose tissue. Conscious, free-feeding animals received central injections of PrRP (4 nmol icv) or vehicle. A single injection at 1000 caused a sustained hyperthermia over the 4-h test period and an increase in the expression of UCP-1 mRNA. Repeated, twice daily injection caused a reduction in body weight gain greater than that seen in pair-fed animals for the first 48-72 h. After 72 h, the animals became refractory to the actions of PrRP. The pair-fed group showed a reduction in UCP-1 mRNA expression at 48 h, which was reversed by PrRP treatment. This study indicates that PrRP exerts its effects on energy homeostasis in the short-medium term by reducing food intake and increasing energy expenditure. <\/jats:p>","DOI":"10.1152\/ajpregu.00237.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:32:01Z","timestamp":1425414721000},"page":"R1005-R1010","source":"Crossref","is-referenced-by-count":32,"title":["Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis"],"prefix":"10.1152","volume":"285","author":[{"given":"Kate L. J.","family":"Ellacott","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn E.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Luckman","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.711"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8871"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01153-1"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1038\/302703a0"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(80)90059-1"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.2.8608"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00028-2"},{"key":"REF8","doi-asserted-by":"crossref","unstructured":"Gibbs J, Falasco JD, and McHugh PR. 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