{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:35:46Z","timestamp":1778272546929,"version":"3.51.4"},"reference-count":27,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p> In vitro, the renin-secreting juxtaglomerular cells express the calcium-sensing receptor, and its activation with the calcimimetic cinacalcet inhibits renin release. To test whether the activation of calcium-sensing receptor similarly inhibits plasma renin activity (PRA) in vivo , we hypothesized that the calcium-sensing receptor is expressed in juxtaglomerular cells in vivo, and acutely administered cinacalcet would inhibit renin activity in anesthetized rats. Since cinacalcet inhibits parathyroid hormone, which may stimulate renin activity, we sought to determine whether cinacalcet inhibits renin activity by decreasing parathyroid hormone. Lastly, we hypothesized that chronically administered cinacalcet would inhibit basal and stimulated renin in conscious rats. Calcium-sensing receptors and renin were localized in the same juxtaglomerular cells using immunofluorescence in rat cortical slices fixed in vivo. Cinacalcet was administered acutely via intravenous bolus in anesthetized rats and chronically in conscious rats by oral gavage. Acute administration of cinacalcet decreased basal renin activity from 13.6 \u00b1 2.4 to 6.1 \u00b1 1.1 ng ANG I\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> ( P &lt; 0.001). Likewise, cinacalcet decreased furosemide-stimulated renin from 30.6 \u00b1 2.3 to 21.3 \u00b1 2.3 ng ANG I\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> ( P &lt; 0.001). In parathyroidectomized rats, cinacalcet decreased renin activity from 9.3 \u00b1 1.3 to 5.2 \u00b1 0.5 ng ANG I\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> ( P &lt; 0.05) similar to sham-operated controls (13.5 \u00b1 2.2 to 6.6 \u00b1 0.8 ng ANG I\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05). Chronic administration of cinacalcet over 7 days had no significant effect on PRA under basal or stimulated conditions. In conclusion, calcium-sensing receptors are expressed in juxtaglomerular cells in vivo, and acute activation of these receptors with cinacalcet inhibits PRA in anesthetized rats, independent of parathyroid hormone. <\/jats:p>","DOI":"10.1152\/ajpregu.00238.2010","type":"journal-article","created":{"date-parts":[[2010,7,22]],"date-time":"2010-07-22T02:03:20Z","timestamp":1279764200000},"page":"R1020-R1026","source":"Crossref","is-referenced-by-count":47,"title":["Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivo"],"prefix":"10.1152","volume":"299","author":[{"given":"Douglas K.","family":"Atchison","sequence":"first","affiliation":[{"name":"Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Cecilia","family":"Ortiz-Capisano","sequence":"additional","affiliation":[{"name":"Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Beierwaltes","sequence":"additional","affiliation":[{"name":"Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan; and"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.269.1.F134"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.5.R1359"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00209.2005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00143.2009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.239"},{"key":"B6","volume-title":"(Cinacalcet-HCl) Product Information Insert","author":"Cinacalcet","year":"2004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.123901"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90021-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-370"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000251057.35537.d3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.57.121304.131328"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1982.tb06972.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1380543"},{"key":"B14","first-page":"181","volume":"89","author":"Kotchen TA","year":"1977","journal-title":"J Lab Clin Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107873"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832f0d22"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00466.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(93)90017-Q"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095158"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00121.2009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000250708.04205.d4"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000255172.84842.d2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197806000-00001"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.1.131"},{"key":"B25","first-page":"248","volume":"47","author":"Rostaing L","year":"1997","journal-title":"Clin Nephrol"},{"key":"B26","first-page":"311","volume":"236","author":"Smith JM","year":"1979","journal-title":"Am J Physiol"},{"key":"B27","first-page":"45","volume":"132","author":"Sotornik Stribrna I","year":"1993","journal-title":"Cas Lek Cesk"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00238.2010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:24:02Z","timestamp":1567959842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00238.2010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1152\/ajpregu.00238.2010"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00238.2010","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}