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In six anesthetized cats, a bladder catheter was inserted via the urethra to infuse saline and measure pressure. A cuff electrode was implanted on the pudendal nerve. After determination of the threshold intensity (T) for PNS to induce an anal twitch, PNS (5\u2009Hz, 0.2\u2009ms, 2\u2009T or 4\u2009T) was applied during cystometrograms (CMGs). PNS (4-6\u2009T) of 30-min duration was then applied repeatedly until bladder underactivity was produced. Following stimulation, control CMGs were performed over 1.5-2\u2009h to determine the duration of bladder underactivity. When applied during CMGs, PNS (2\u2009T and 4\u2009T) significantly ( P &lt; 0.05) increased bladder capacity while PNS at 4\u2009T also significantly ( P &lt; 0.05) reduced bladder contraction amplitude, duration, and area under contraction curve. Repeated application of 30-min PNS for a cumulative period of 3-8\u2009h produced bladder underactivity exhibiting a significantly ( P &lt; 0.05) increased bladder capacity (173\u2009\u00b1\u200914% of control) and a significantly ( P &lt; 0.05) reduced contraction amplitude (50\u2009\u00b1\u20097% of control). The bladder underactivity lasted more than 1.5-2\u2009h after termination of the prolonged PNS. These results provide basic science evidence supporting the proposal that abnormal afferent activity from external urethral\/anal sphincter could produce central inhibition that underlies nonobstructive urinary retention (NOUR) in Fowler\u2019s syndrome. This cat model of UAB may be useful to investigate the mechanism by which sacral neuromodulation reverses NOUR in Fowler\u2019s syndrome. <\/jats:p>","DOI":"10.1152\/ajpregu.00239.2020","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T16:30:56Z","timestamp":1604507456000},"page":"R80-R87","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Bladder underactivity induced by prolonged pudendal afferent activity in cats"],"prefix":"10.1152","volume":"320","author":[{"given":"Anand","family":"Mohapatra","sequence":"first","affiliation":[{"name":"Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Urology, The Third Affiliated 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