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BBS1 protein, which is a key component of the BBSome, a protein complex involved in the regulation of cilia function and other cellular processes, has been implicated in the immune synapse assembly by promoting the centrosome polarization to the antigen-presenting cells. Here, we assessed the effect of disrupting the BBSome, through Bbs1 gene deletion, in T cells. Interestingly, mice lacking the Bbs1 gene specifically in T cells ( T-BBS1<jats:sup>\u2212\/\u2212<\/jats:sup>) displayed normal body weight, adiposity, and glucose handling, but have smaller spleens. However, T-BBS1<jats:sup>\u2212\/\u2212<\/jats:sup> mice had no change in the proportion and absolute number of B cells and T cells in the spleen and lymph nodes. There was also no alteration in the CD4\/CD8 lineage commitment or survival in the thymus of T-BBS1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. On the other hand, T-BBS1<jats:sup>\u2212\/\u2212<\/jats:sup> mice treated with Imiquimod dermally exhibited a significantly higher percentage of CD3-positive splenocytes that was due to CD4 but not CD8 T cell predominance. Notably, we found that T-BBS1<jats:sup>\u2212\/\u2212<\/jats:sup> mice had significantly decreased wound closure, an effect that was more pronounced in males indicating that the BBSome plays an important role in T cell-mediated skin repair. Together, these findings implicate the BBSome in the regulation of selective functions of T cells. <\/jats:p>","DOI":"10.1152\/ajpregu.00243.2022","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T17:31:40Z","timestamp":1671471100000},"page":"R161-R170","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses"],"prefix":"10.1152","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-5994","authenticated-orcid":false,"given":"Madeliene","family":"Stump","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Physician Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng Fu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Veterans Affairs Health Care System, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-6748","authenticated-orcid":false,"given":"Kamal","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Veterans Affairs Health Care System, Iowa City, Iowa"},{"name":"Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa"},{"name":"Obesity Research 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