{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:08:28Z","timestamp":1789772908687,"version":"4.0.1"},"reference-count":61,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100001505","name":"Manatu Hauora | Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001516","name":"National Heart Foundation of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001516","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p> Activation of the carotid body (CB) using intracarotid potassium cyanide (KCN) injection increases coronary blood flow (CoBF). This increase in CoBF is considered to be mediated by co-activation of both the sympathetic and parasympathetic nerves to the heart. However, whether cardiac sympathetic nerve activity (cardiac SNA) actually increases during CB activation has not been determined previously. We hypothesized that activation of the CB would increase directly recorded cardiac SNA, which would cause coronary vasodilatation. Experiments were conducted in conscious sheep implanted with electrodes to record cardiac SNA and diaphragmatic electromyography (dEMG), flow probes to record CoBF and cardiac output, and a catheter to record arterial pressure. Intracarotid KCN injection was used to activate the CB. To eliminate the contribution of metabolic demand on coronary flow, the heart was paced at a constant rate during CB chemoreflex stimulation. Intracarotid KCN injection resulted in a significant increase in directly recorded cardiac SNA frequency (from 24\u2009\u00b1\u20092 to 40\u2009\u00b1\u20094 bursts\/min; P &lt; 0.05) as well as a dose-dependent increase in mean arterial pressure (79\u2009\u00b1\u200915 to 88\u2009\u00b1\u200914\u2009mmHg; P &lt; 0.01) and CoBF (75\u2009\u00b1\u200937 vs. 86\u2009\u00b1\u200942\u2009mL\/min; P &lt; 0.05). The increase in CoBF and coronary vascular conductance to intracarotid KCN injection was abolished after propranolol infusion, suggesting that the increased cardiac SNA mediates coronary vasodilatation. The pressor response to activation of the CB was abolished by pretreatment with intravenous atropine, but there was no change in the coronary flow response. Our results indicate that CB activation increases directly recorded cardiac SNA, which mediates vasodilatation of the coronary vasculature. <\/jats:p>","DOI":"10.1152\/ajpregu.00246.2020","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T19:06:55Z","timestamp":1605726415000},"page":"R203-R212","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Activation of the carotid body increases directly recorded cardiac sympathetic nerve activity and coronary blood flow in conscious sheep"],"prefix":"10.1152","volume":"320","author":[{"given":"Mridula","family":"Pachen","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonis","family":"Abukar","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New 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