{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:13:00Z","timestamp":1763536380674,"version":"build-2065373602"},"reference-count":27,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    This large pediatric cohort study confirms the safety of the water deprivation test but reveals its limited diagnostic accuracy. Updated diagnostic criteria can improve performance and reduce unnecessary testing. A baseline urinary osmolality (uOsm) &gt; 279 mOsm\/kgH\n                    <jats:sub>2<\/jats:sub>\n                    O excluded arginine vasopressin (AVP) disorders with 100% sensitivity and 74% specificity and an interrupt uOsm &gt; 533 mOsm\/kgH\n                    <jats:sub>2<\/jats:sub>\n                    O excluded them with 100% sensitivity and specificity. A weight loss &gt;5% was a safe threshold. Prospective, multicenter studies are needed to generalize these findings.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00248.2024","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T18:01:49Z","timestamp":1757527309000},"page":"R692-R702","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Water deprivation test in children: challenging but still necessary for the differential diagnosis of polyuria-polydipsia syndrome"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-2115","authenticated-orcid":false,"given":"Carolina Donaire","family":"Sousa","sequence":"first","affiliation":[{"name":"University of Sao Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Gon Perez","family":"Nardoque","sequence":"additional","affiliation":[{"name":"University of Sao 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