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We hypothesized that reductions in carotid chemoreceptor activity would attenuate the sympathoexcitatory response to hyperinsulinemia. Young, healthy adults (9 male\/9 female, 28\u2009\u00b1\u20091 yr, 24\u2009\u00b1\u20091 kg\/m<jats:sup>2<\/jats:sup>) completed a 30-min euglycemic baseline followed by a 90-min hyperinsulinemic (1 mU\u00b7kg fat-free mass<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), euglycemic infusion. MSNA (microneurography of the peroneal nerve) was continuously measured. The role of the carotid chemoreceptors was assessed at baseline and during hyperinsulinemia via 1) acute hyperoxia, 2) low-dose dopamine (1\u20134 \u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>), and 3) acute hyperoxia + low-dose dopamine. MSNA burst frequency increased from baseline during hyperinsulinemia ( P &lt; 0.01). Acute hyperoxia had no effect on MSNA burst frequency at rest ( P = 0.74) or during hyperinsulinemia ( P = 0.83). The insulin-mediated increase in MSNA burst frequency ( P = 0.02) was unaffected by low-dose dopamine ( P = 0.60). When combined with low-dose dopamine, acute hyperoxia had no effect on MSNA burst frequency at rest ( P = 0.17) or during hyperinsulinemia ( P = 0.85). Carotid chemoreceptor desensitization in young, healthy men and women does not attenuate the sympathoexcitatory response to hyperinsulinemia. Our data suggest that the carotid chemoreceptors do not contribute to acute insulin-mediated increases in MSNA in young, healthy adults.<\/jats:p>","DOI":"10.1152\/ajpregu.00257.2019","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T15:43:19Z","timestamp":1574264599000},"page":"R173-R181","source":"Crossref","is-referenced-by-count":17,"title":["Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans"],"prefix":"10.1152","volume":"318","author":[{"given":"Jacqueline K.","family":"Limberg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1731-4415","authenticated-orcid":false,"given":"Blair 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