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Beyond the well-defined contribution of more traditional pathophysiological mechanisms, such as changes in the renin\u2013angiotensin\u2013aldosterone system, to the development of these hypertensive disorders, there is substantial clinical evidence supporting an important role for inflammation and immunity in the pathogenesis of each of these three conditions. Over the last decade, work in small animal models, bearing targeted deficiencies in specific cytokines or immune cell subsets, has begun to clarify the immune-mediated mechanisms that drive changes in vascular structure and tone in hypertensive disease. By summarizing the clinical and experimental evidence supporting a contribution of the immune system to systemic hypertension, preeclampsia, and PAH, the current review highlights the cellular and molecular pathways that are common to all three hypertensive disorders. These mechanisms are centered on an imbalance in CD4<jats:sup>+<\/jats:sup>helper T cell populations, defined by excessive Th17 responses and impaired T<jats:sub>reg<\/jats:sub>activity, as well as the excessive activation or impairment of additional immune cell types, including macrophages, dendritic cells, CD8<jats:sup>+<\/jats:sup>T cells, B cells, and natural killer cells. 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