{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:51:54Z","timestamp":1780645914738,"version":"3.54.1"},"reference-count":63,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"HHS | NIH | National Institute on Aging","award":["R01AG069005"],"award-info":[{"award-number":["R01AG069005"]}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["F32HL168826"],"award-info":[{"award-number":["F32HL168826"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["23POST1023065"],"award-info":[{"award-number":["23POST1023065"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["24POST1192222"],"award-info":[{"award-number":["24POST1192222"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>There is considerable heterogeneity in the thermal and cardiovascular responses to heat stress, even among older adults within a similar age range; hence, age alone may not predict heat-related risks. This variability may be in part explained by differences in physical fitness. Our findings show that individuals with low left ventricular end-diastolic volumes have greater core temperature and heart rate responses to environmental heat stress.<\/jats:p>","DOI":"10.1152\/ajpregu.00276.2025","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T16:21:56Z","timestamp":1766766116000},"page":"R85-R93","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of left ventricular end-diastolic volume with core temperature and heart rate during very hot and dry heat stress in older adults"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-8870","authenticated-orcid":false,"given":"Zachary J.","family":"McKenna","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["United States"]},{"name":"Texas Health Presbyterian Hospital Dallas","place":["United States"]},{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-4919","authenticated-orcid":false,"given":"Satyam","family":"Sarma","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["United States"]},{"name":"Texas Health Presbyterian Hospital Dallas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-048X","authenticated-orcid":false,"given":"Whitley C.","family":"Atkins","sequence":"additional","affiliation":[{"name":"University of New Mexico","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6877-681X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Gideon","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["United States"]},{"name":"Texas Health Presbyterian Hospital Dallas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4518-4487","authenticated-orcid":false,"given":"Jacob L.","family":"McNary","sequence":"additional","affiliation":[{"name":"Texas Health Presbyterian Hospital Dallas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-9713","authenticated-orcid":false,"given":"Craig G.","family":"Crandall","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["United States"]},{"name":"Texas Health Presbyterian Hospital Dallas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323615"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.12957"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15715"},{"key":"B4","first-page":"6","volume":"25","author":"Johnson H","year":"2005","journal-title":"Health Stat Q"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11594"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckm108"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-3797(99)00025-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(22)00117-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2023"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00227.2023"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.5.R1050"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.3.1082"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350203"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-006-0089-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.3.671"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.1.236"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1126"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/20.6.439"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/EP088783"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00105.2001"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb51777.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.4.1863"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00188.2003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4081\/jphr.2020.1840"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160275"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.011"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.1.160"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2020.12.007"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)91027-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010775"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.517"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.1.134"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22928"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.819938"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.040490"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.101444"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00390.2025"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(75)90069-9"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.29.020907.090843"},{"key":"B41","first-page":"1","volume":"76","author":"Berko J","year":"2014","journal-title":"Natl Health Stat Report"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.buildenv.2013.03.011"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.buildenv.2018.07.045"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00191.2018"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2020.1801119"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2019.05.010"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.026344"},{"key":"B49","first-page":"303","volume":"5","author":"Du Bois D","year":"1989","journal-title":"Nutrition"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000548"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0327-9"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195712"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01975-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0642-3"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00917.2024"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.170381"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00643.2016"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.083014"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01069.2008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1912.sp001511"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2807\/esm.10.07.00555-en"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(19)30090-7"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.12.004"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00276.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:46:24Z","timestamp":1768229184000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00276.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpregu.00276.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00276.2025","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}