{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:12:07Z","timestamp":1774303927643,"version":"3.50.1"},"reference-count":27,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-094905"],"award-info":[{"award-number":["DK-094905"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-102427"],"award-info":[{"award-number":["DK-102427"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-111382"],"award-info":[{"award-number":["DK-111382"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p> This study tested the hypothesis that sacral neuromodulation, i.e., electrical stimulation of afferent axons in sacral spinal root, can block pudendal afferent inhibition of the micturition reflex. In \u03b1-chloralose-anesthetized cats, pudendal nerve stimulation (PNS) at 3\u20135 Hz was used to inhibit bladder reflex activity while the sacral S1 or S2 dorsal root was stimulated at 15\u201330 Hz to mimic sacral neuromodulation and to block the bladder inhibition induced by PNS. The intensity threshold (T) for PNS or S1\/S2 dorsal root stimulation (DRS) to induce muscle twitch of anal sphincter or toe was determined. PNS at 1.5\u20132T intensity inhibited the micturition reflex by significantly ( P &lt; 0.01) increasing bladder capacity to 150\u2013170% of control capacity. S1 DRS alone at 1\u20131.5T intensity did not inhibit bladder activity but completely blocked PNS inhibition and restored bladder capacity to control level. At higher intensity (1.5\u20132T), S1 DRS alone inhibited the micturition reflex and significantly increased bladder capacity to 135.8\u2009\u00b1\u20096.6% of control capacity. However, the same higher intensity S1 DRS applied simultaneously with PNS, suppressed PNS inhibition and significantly ( P &lt; 0.01) reduced bladder capacity to 126.8 \u00b1 9.7% of control capacity. S2 DRS at both low (1T) and high (1.5\u20132T) intensity failed to significantly reduce PNS inhibition. PNS and S1 DRS did not change the amplitude and duration of micturition reflex contractions, but S2 DRS at 1.5\u20132T intensity doubled the duration of the contractions and increased bladder capacity. These results are important for understanding the mechanisms underlying sacral neuromodulation of nonobstructive urinary retention in Fowler\u2019s syndrome. <\/jats:p>","DOI":"10.1152\/ajpregu.00285.2017","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T20:50:16Z","timestamp":1505940616000},"page":"R34-R42","source":"Crossref","is-referenced-by-count":12,"title":["Sacral neuromodulation blocks pudendal inhibition of reflex bladder activity in cats: insight into the efficacy of sacral neuromodulation in Fowler\u2019s syndrome"],"prefix":"10.1152","volume":"314","author":[{"given":"Xing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical University, Beijing, People\u2019s Republic of China"},{"name":"Department of Urology, University of Pittsburgh, Pittsburgh, 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